Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Holy Cross | 51 | Morgan State | 24 | Final | W | 27 |
| 2 | 2016-09-10 | Holy Cross | 28 | New Hampshire | 39 | Final | L | -11 |
| 3 | 2016-09-17 | Holy Cross | 28 | Albany | 45 | Final | L | -17 |
| 4 | 2016-09-24 | Dartmouth | 35 | Holy Cross | 10 | Final | L | -25 |
| 5 | 2016-10-01 | Holy Cross | 38 | Lafayette | 28 | Final | W | 10 |
| 6 | 2016-10-08 | Bucknell | 21 | Holy Cross | 20 | Final | L | -1 |
| 7 | 2016-10-15 | Harvard | 17 | Holy Cross | 27 | Final | W | 10 |
| 8 | 2016-10-22 | Lehigh | 46 | Holy Cross | 14 | Final | L | -32 |
| 9 | 2016-10-29 | Holy Cross (206) | 8 | Colgate (187) | 26 | Final | L | -18 |
| 10 | 2016-11-05 | Holy Cross (210) | 21 | Georgetown (212) | 20 | Final | W | 1 |
| 11 | 2016-11-12 | Fordham (168) | 54 | Holy Cross (206) | 14 | Final | L | -40 |