Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-08-27 | Duquesne (173) | 7 | Florida State (74) | 47 | Final | L | -40 |
| 2 | 2022-09-03 | Duquesne (173) | 14 | Youngstown State (176) | 31 | Final | L | -17 |
| 3 | 2022-09-10 | Thomas More | 14 | Duquesne (173) | 34 | Final | W | 20 |
| 4 | 2022-09-18 | Duquesne (215) | 14 | Hawaii (128) | 24 | Final | L | -10 |
| 5 | 2022-10-01 | Duquesne (227) | 20 | Stonehill (171) | 24 | Final | L | -4 |
| 6 | 2022-10-08 | Merrimack (153) | 28 | Duquesne (230) | 21 | Final | L | -7 |
| 7 | 2022-10-22 | Duquesne (225) | 30 | Central Connecticut State (257) | 6 | Final | W | 24 |
| 8 | 2022-10-29 | Long Island (245) | 50 | Duquesne (233) | 48 | Final(2OT) | L | -2 |
| 9 | 2022-11-05 | Sacred Heart (223) | 28 | Duquesne (224) | 35 | Final(OT) | W | 7 |
| 10 | 2022-11-19 | Wagner (257) | 0 | Duquesne (218) | 33 | Final | W | 33 |