Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-09-12 | Clemson (3) | 37 | Wake Forest (47) | 13 | Final | W | 24 |
| 2 | 2020-09-19 | The Citadel (178) | 0 | Clemson (3) | 49 | Final | W | 49 |
| 3 | 2020-10-03 | Virginia (27) | 23 | Clemson (17) | 41 | Final | W | 18 |
| 4 | 2020-10-10 | Miami (3) | 17 | Clemson (6) | 42 | Final | W | 25 |
| 5 | 2020-10-17 | Clemson (3) | 73 | Georgia Tech (109) | 7 | Final | W | 66 |
| 6 | 2020-10-24 | Syracuse (118) | 21 | Clemson (2) | 47 | Final | W | 26 |
| 7 | 2020-10-31 | Boston College (44) | 28 | Clemson (1) | 34 | Final | W | 6 |
| 8 | 2020-11-07 | Clemson (1) | 40 | Notre Dame (7) | 47 | Final(2OT) | L | -7 |
| 9 | 2020-11-21 | Clemson (5) | 0 | Florida State (112) | 0 | Cancelled | - | - |
| 10 | 2020-11-28 | Pittsburgh (48) | 17 | Clemson (5) | 52 | Final | W | 35 |
| 11 | 2020-12-05 | Clemson (5) | 45 | Virginia Tech (55) | 10 | Final | W | 35 |
| 12 | 2020-12-19 | Clemson (4) | 34 | Notre Dame (3) | 10 | Final | W | 24 |
| 13 | 2021-01-01 | Ohio State (6) | 49 | Clemson (2) | 28 | Final | L | -21 |