Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | Arizona (154) | 38 | San Diego State (19) | 20 | Final | W | 18 |
| 2 | 2022-09-10 | Mississippi State (80) | 39 | Arizona (154) | 17 | Final | L | -22 |
| 3 | 2022-09-17 | North Dakota State (154) | 28 | Arizona (80) | 31 | Final | W | 3 |
| 4 | 2022-09-24 | Arizona (83) | 31 | California (46) | 49 | Final | L | -18 |
| 5 | 2022-10-01 | Colorado (133) | 20 | Arizona (76) | 43 | Final | W | 23 |
| 6 | 2022-10-08 | Oregon (17) | 49 | Arizona (80) | 22 | Final | L | -27 |
| 7 | 2022-10-15 | Arizona (91) | 39 | Washington (36) | 49 | Final | L | -10 |
| 8 | 2022-10-29 | USC (10) | 45 | Arizona (91) | 37 | Final | L | -8 |
| 9 | 2022-11-05 | Arizona (91) | 20 | Utah (14) | 45 | Final | L | -25 |
| 10 | 2022-11-12 | Arizona (74) | 34 | UCLA (18) | 28 | Final | W | 6 |
| 11 | 2022-11-19 | Washington State (38) | 31 | Arizona (77) | 20 | Final | L | -11 |
| 12 | 2022-11-25 | Arizona State (103) | 35 | Arizona (71) | 38 | Final | W | 3 |