Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-08-30 | Ball State (130) | 0 | Purdue (133) | 31 | Final | W | 31 |
| 2 | 2025-09-06 | Southern Illinois (184) | 0 | Purdue (133) | 0 | Scheduled – 7:30 PM | – | – |
| 3 | 2025-09-13 | USC (30) | 0 | Purdue (133) | 0 | Scheduled – 3:30 PM | – | – |
| 4 | 2025-09-20 | Purdue (133) | 0 | Notre Dame (3) | 0 | Scheduled – 3:30 PM | – | – |
| 5 | 2025-10-04 | Illinois (17) | 0 | Purdue (133) | 0 | Scheduled – TBD | – | – |
| 6 | 2025-10-10 | Purdue (133) | 0 | Minnesota (32) | 0 | Scheduled – TBD | – | – |
| 7 | 2025-10-17 | Purdue (133) | 0 | Northwestern (90) | 0 | Scheduled – TBD | – | – |
| 8 | 2025-10-25 | Rutgers (52) | 0 | Purdue (133) | 0 | Scheduled – TBD | – | – |
| 9 | 2025-11-01 | Purdue (133) | 0 | Michigan (18) | 0 | Scheduled – TBD | – | – |
| 10 | 2025-11-08 | Ohio State (1) | 0 | Purdue (133) | 0 | Scheduled – TBD | – | – |
| 11 | 2025-11-14 | Purdue (133) | 0 | Washington (49) | 0 | Scheduled – TBD | – | – |
| 12 | 2025-11-28 | Indiana (6) | 0 | Purdue (133) | 0 | Scheduled – 7:30 PM | – | – |