Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-11-13 | Air Force (209) | 75 | 77 | Southern Illinois (252) | Final | W | 2 |
| 2 | 2015-11-15 | Florida A&M (350) | 51 | 81 | Southern Illinois (252) | Final | W | 30 |
| 3 | 2015-11-18 | Kent State (116) | 69 | 72 | Southern Illinois (252) | Final | W | 3 |
| 4 | 2015-11-21 | Southern Illinois (252) | 86 | 81 | Sam Houston State (92) | Final/OT | W | 5 |
| 5 | 2015-11-24 | Oakland (171) | 88 | 97 | Southern Illinois (252) | Final | W | 9 |
| 6 | 2015-11-27 | Southern Illinois (252) | 66 | 71 | UTEP (91) | Final | L | -5 |
| 7 | 2015-11-28 | Southern Illinois (252) | 80 | 79 | Portland (136) | Final | W | 1 |
| 8 | 2015-12-02 | Southeast Missouri State (258) | 50 | 74 | Southern Illinois (252) | Final | W | 24 |
| 9 | 2015-12-05 | Southern Illinois (252) | 95 | 63 | North Texas (229) | Final | W | 32 |
| 10 | 2015-12-09 | SIU-Edwardsville (295) | 76 | 74 | Southern Illinois (45) | Final | L | -2 |
| 11 | 2015-12-12 | North Texas (313) | 66 | 74 | Southern Illinois (45) | Final | W | 8 |
| 12 | 2015-12-18 | Southern Illinois (55) | 88 | 73 | Murray State (165) | Final | W | 15 |
| 13 | 2015-12-21 | Southern Illinois (55) | 65 | 52 | Saint Louis (131) | Final | W | 13 |
| 14 | 2015-12-30 | Southern Illinois (49) | 72 | 62 | Loyola-Chicago (177) | Final | W | 10 |
| 15 | 2016-01-02 | Northern Iowa (93) | 73 | 75 | Southern Illinois (49) | Final | W | 2 |
| 16 | 2016-01-06 | Southern Illinois (43) | 65 | 44 | Bradley (327) | Final | W | 21 |
| 17 | 2016-01-09 | Wichita State (78) | 83 | 58 | Southern Illinois (43) | Final | L | -25 |
| 18 | 2016-01-12 | Illinois State (166) | 78 | 81 | Southern Illinois (86) | Final | W | 3 |
| 19 | 2016-01-17 | Southern Illinois (86) | 81 | 76 | Drake (246) | Final | W | 5 |
| 20 | 2016-01-20 | Indiana State (139) | 66 | 79 | Southern Illinois (87) | Final | W | 13 |
| 21 | 2016-01-24 | Southern Illinois (87) | 80 | 65 | Missouri State (218) | Final | W | 15 |
| 22 | 2016-01-28 | Evansville (66) | 85 | 78 | Southern Illinois (73) | Final/OT | L | -7 |
| 23 | 2016-01-31 | Southern Illinois (73) | 58 | 67 | Northern Iowa (149) | Final | L | -9 |
| 24 | 2016-02-03 | Southern Illinois (100) | 55 | 76 | Wichita State (38) | Final | L | -21 |
| 25 | 2016-02-06 | Loyola-Chicago (203) | 73 | 59 | Southern Illinois (100) | Final | L | -14 |
| 26 | 2016-02-10 | Southern Illinois (107) | 85 | 78 | Indiana State (151) | Final | W | 7 |
| 27 | 2016-02-13 | Drake (279) | 60 | 75 | Southern Illinois (107) | Final | W | 15 |
| 28 | 2016-02-17 | Bradley (324) | 59 | 71 | Southern Illinois (104) | Final | W | 12 |
| 29 | 2016-02-20 | Southern Illinois (104) | 71 | 83 | Evansville (85) | Final | L | -12 |
| 30 | 2016-02-24 | Southern Illinois (105) | 50 | 73 | Illinois State (125) | Final | L | -23 |
| 31 | 2016-02-27 | Missouri State (212) | 68 | 78 | Southern Illinois (105) | Final | W | 10 |
| 32 | 2016-03-04 | Southern Illinois (112) | 60 | 66 | Northern Iowa (100) | Final | L | -6 |