Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-11-13 | Southeast Missouri State (258) | 53 | 84 | Dayton (41) | Final | L | -31 |
| 2 | 2015-11-15 | Southeast Missouri State (258) | 65 | 80 | Evansville (112) | Final | L | -15 |
| 3 | 2015-11-19 | Southeast Missouri State (258) | 56 | 74 | Alabama A&M (340) | Final | L | -18 |
| 4 | 2015-11-24 | Southeast Missouri State (258) | 74 | 83 | UTRGV | Final | L | -9 |
| 5 | 2015-11-28 | Loyola Marymount (251) | 73 | 60 | Southeast Missouri State (258) | Final | L | -13 |
| 6 | 2015-12-02 | Southeast Missouri State (258) | 50 | 74 | Southern Illinois (252) | Final | L | -24 |
| 7 | 2015-12-05 | Southeast Missouri State (258) | 65 | 80 | Memphis (84) | Final | L | -15 |
| 8 | 2015-12-08 | Bowling Green (143) | 79 | 52 | Southeast Missouri State (343) | Final | L | -27 |
| 9 | 2015-12-12 | Ole Miss (92) | 75 | 64 | Southeast Missouri State (343) | Final | L | -11 |
| 10 | 2015-12-19 | Southeast Missouri State (346) | 69 | 79 | Northern Kentucky (289) | Final | L | -10 |
| 11 | 2015-12-22 | Southeast Missouri State (348) | 78 | 74 | Missouri State (215) | Final | W | 4 |
| 12 | 2015-12-27 | Harris Stowe | 84 | 94 | Southeast Missouri State (348) | Final | W | 10 |
| 13 | 2015-12-31 | Belmont (154) | 92 | 82 | Southeast Missouri State (334) | Final | L | -10 |
| 14 | 2016-01-02 | Tennessee State (194) | 72 | 66 | Southeast Missouri State (334) | Final | L | -6 |
| 15 | 2016-01-07 | Southeast Missouri State (338) | 69 | 96 | Morehead State (185) | Final | L | -27 |
| 16 | 2016-01-09 | Southeast Missouri State (338) | 69 | 88 | Eastern Kentucky (180) | Final | L | -19 |
| 17 | 2016-01-13 | Jacksonville State (324) | 74 | 60 | Southeast Missouri State (342) | Final | L | -14 |
| 18 | 2016-01-16 | Southeast Missouri State (342) | 55 | 91 | Tennessee Tech (146) | Final | L | -36 |
| 19 | 2016-01-19 | Hannibal-LaGrange | 61 | 84 | Southeast Missouri State (348) | Final | W | 23 |
| 20 | 2016-01-23 | Tennessee-Martin (220) | 0 | 0 | Southeast Missouri State (348) | Postponed | - | - |
| 21 | 2016-01-24 | Tennessee-Martin (220) | 60 | 68 | Southeast Missouri State (348) | Final/OT | W | 8 |
| 22 | 2016-01-28 | Southeast Missouri State (338) | 58 | 51 | SIU-Edwardsville (286) | Final | W | 7 |
| 23 | 2016-01-30 | Austin Peay (237) | 86 | 80 | Southeast Missouri State (338) | Final | L | -6 |
| 24 | 2016-02-04 | Murray State (184) | 78 | 72 | Southeast Missouri State (335) | Final | L | -6 |
| 25 | 2016-02-06 | Southeast Missouri State (335) | 69 | 78 | Eastern Illinois (249) | Final | L | -9 |
| 26 | 2016-02-11 | Southeast Missouri State (335) | 64 | 77 | Tennessee-Martin (222) | Final | L | -13 |
| 27 | 2016-02-13 | Southeast Missouri State (335) | 56 | 83 | Murray State (186) | Final | L | -27 |
| 28 | 2016-02-18 | SIU-Edwardsville (303) | 72 | 69 | Southeast Missouri State (340) | Final | L | -3 |
| 29 | 2016-02-20 | Eastern Illinois (260) | 71 | 68 | Southeast Missouri State (340) | Final | L | -3 |
| 30 | 2016-02-27 | Southeast Missouri State (344) | 75 | 83 | Austin Peay (243) | Final | L | -8 |