Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-11-13 | Arkansas State (293) | 70 | 79 | SIU-Edwardsville (262) | Final | W | 9 |
| 2 | 2015-11-18 | Saint Louis (239) | 70 | 60 | SIU-Edwardsville (262) | Final | L | -10 |
| 3 | 2015-11-21 | SIU-Edwardsville (262) | 67 | 87 | Purdue Fort Wayne (214) | Final | L | -20 |
| 4 | 2015-11-24 | Campbell (311) | 77 | 74 | SIU-Edwardsville (262) | Final | L | -3 |
| 5 | 2015-11-28 | SIU-Edwardsville (262) | 73 | 89 | Butler (23) | Final | L | -16 |
| 6 | 2015-11-30 | Green Bay (79) | 87 | 69 | SIU-Edwardsville (262) | Final | L | -18 |
| 7 | 2015-12-03 | SIU-Edwardsville (262) | 51 | 64 | Milwaukee (222) | Final | L | -13 |
| 8 | 2015-12-05 | SIU-Edwardsville (262) | 56 | 81 | Northwestern (94) | Final | L | -25 |
| 9 | 2015-12-09 | SIU-Edwardsville (295) | 76 | 74 | Southern Illinois (45) | Final | W | 2 |
| 10 | 2015-12-12 | Portland State (257) | 64 | 74 | SIU-Edwardsville (295) | Final | W | 10 |
| 11 | 2015-12-21 | SIU-Edwardsville (284) | 51 | 70 | USC (26) | Final | L | -19 |
| 12 | 2015-12-28 | Grand Canyon (102) | 86 | 75 | SIU-Edwardsville (288) | Final | L | -11 |
| 13 | 2015-12-31 | SIU-Edwardsville (284) | 67 | 72 | Jacksonville State (310) | Final | L | -5 |
| 14 | 2016-01-02 | SIU-Edwardsville (284) | 63 | 86 | Tennessee Tech (179) | Final | L | -23 |
| 15 | 2016-01-06 | Belmont (140) | 85 | 77 | SIU-Edwardsville (281) | Final | L | -8 |
| 16 | 2016-01-09 | SIU-Edwardsville (281) | 60 | 63 | Tennessee State (191) | Final | L | -3 |
| 17 | 2016-01-14 | Morehead State (163) | 70 | 67 | SIU-Edwardsville (283) | Final/OT | L | -3 |
| 18 | 2016-01-16 | Eastern Kentucky (184) | 65 | 67 | SIU-Edwardsville (283) | Final | W | 2 |
| 19 | 2016-01-21 | SIU-Edwardsville (270) | 86 | 90 | Austin Peay (232) | Final/OT | L | -4 |
| 20 | 2016-01-23 | SIU-Edwardsville (270) | 54 | 70 | Murray State (188) | Final | L | -16 |
| 21 | 2016-01-28 | Southeast Missouri State (338) | 58 | 51 | SIU-Edwardsville (286) | Final | L | -7 |
| 22 | 2016-01-30 | Eastern Illinois (263) | 60 | 46 | SIU-Edwardsville (286) | Final | L | -14 |
| 23 | 2016-02-06 | Tennessee-Martin (236) | 79 | 62 | SIU-Edwardsville (308) | Final | L | -17 |
| 24 | 2016-02-11 | Murray State (186) | 70 | 64 | SIU-Edwardsville (316) | Final | L | -6 |
| 25 | 2016-02-13 | SIU-Edwardsville (316) | 72 | 64 | Eastern Illinois (243) | Final | W | 8 |
| 26 | 2016-02-18 | SIU-Edwardsville (303) | 72 | 69 | Southeast Missouri State (340) | Final | W | 3 |
| 27 | 2016-02-20 | SIU-Edwardsville (303) | 51 | 68 | Tennessee-Martin (213) | Final | L | -17 |
| 28 | 2016-02-25 | Austin Peay (243) | 80 | 75 | SIU-Edwardsville (304) | Final | L | -5 |