Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-11-10 | Campbell (248) | 75 | 86 | Penn State (81) | Final | W | 11 |
| 2 | 2017-11-12 | Fairleigh Dickinson (289) | 57 | 81 | Penn State (81) | Final | W | 24 |
| 3 | 2017-11-15 | Montana (206) | 57 | 70 | Penn State (81) | Final | W | 13 |
| 4 | 2017-11-17 | Columbia (249) | 65 | 79 | Penn State (81) | Final | W | 14 |
| 5 | 2017-11-20 | Penn State (81) | 85 | 54 | Pittsburgh (69) | Final | W | 31 |
| 6 | 2017-11-21 | Penn State (16) | 87 | 98 | Texas A&M (29) | Final | L | -11 |
| 7 | 2017-11-24 | Oral Roberts (323) | 48 | 86 | Penn State (16) | Final | W | 38 |
| 8 | 2017-11-29 | Penn State (33) | 78 | 85 | North Carolina State (76) | Final | L | -7 |
| 9 | 2017-12-02 | Penn State (33) | 77 | 73 | Iowa (143) | Final | W | 4 |
| 10 | 2017-12-04 | Wisconsin (93) | 64 | 63 | Penn State (33) | Final | L | -1 |
| 11 | 2017-12-09 | George Washington (136) | 54 | 74 | Penn State (49) | Final | W | 20 |
| 12 | 2017-12-17 | Penn State (65) | 72 | 54 | George Mason (181) | Final | W | 18 |
| 13 | 2017-12-19 | Binghamton (193) | 65 | 80 | Penn State (58) | Final | W | 15 |
| 14 | 2017-12-22 | Rider (155) | 71 | 70 | Penn State (58) | Final | L | -1 |
| 15 | 2017-12-30 | Coppin State (348) | 43 | 88 | Penn State (68) | Final | W | 45 |
| 16 | 2018-01-02 | Penn State (68) | 69 | 75 | Maryland (37) | Final | L | -6 |
| 17 | 2018-01-05 | Northwestern (74) | 63 | 78 | Penn State (68) | Final | W | 15 |
| 18 | 2018-01-09 | Penn State (64) | 70 | 74 | Indiana (104) | Final | L | -4 |
| 19 | 2018-01-12 | Nebraska (74) | 74 | 76 | Penn State (64) | Final/OT | W | 2 |
| 20 | 2018-01-15 | Minnesota (51) | 95 | 84 | Penn State (64) | Final/OT | L | -11 |
| 21 | 2018-01-20 | Penn State (66) | 61 | 70 | Northwestern (88) | Final | L | -9 |
| 22 | 2018-01-25 | Penn State (79) | 82 | 79 | Ohio State (13) | Final | W | 3 |
| 23 | 2018-01-27 | Rutgers (105) | 43 | 60 | Penn State (79) | Final | W | 17 |
| 24 | 2018-01-31 | Penn State (70) | 68 | 76 | Michigan State (6) | Final | L | -8 |
| 25 | 2018-02-03 | Iowa (116) | 58 | 82 | Penn State (70) | Final | W | 24 |
| 26 | 2018-02-07 | Maryland (54) | 70 | 74 | Penn State (60) | Final | W | 4 |
| 27 | 2018-02-11 | Penn State (60) | 74 | 52 | Illinois (102) | Final | W | 22 |
| 28 | 2018-02-15 | Ohio State (12) | 56 | 79 | Penn State (56) | Final | W | 23 |
| 29 | 2018-02-18 | Penn State (56) | 73 | 76 | Purdue (5) | Final | L | -3 |
| 30 | 2018-02-21 | Michigan (23) | 72 | 63 | Penn State (50) | Final | L | -9 |
| 31 | 2018-02-25 | Penn State (50) | 64 | 76 | Nebraska (55) | Final | L | -12 |
| 32 | 2018-03-01 | Northwestern (98) | 57 | 65 | Penn State (58) | Final | W | 8 |
| 33 | 2018-03-02 | Penn State (58) | 69 | 68 | Ohio State (16) | Final | W | 1 |
| 34 | 2018-03-03 | Penn State (58) | 70 | 78 | Purdue (6) | Final | L | -8 |
| 35 | 2018-03-14 | Temple (77) | 57 | 63 | Penn State (52) | Final | W | 6 |
| 36 | 2018-03-17 | Penn State (52) | 73 | 63 | Notre Dame (51) | Final | W | 10 |
| 37 | 2018-03-20 | Penn State (52) | 85 | 80 | Marquette (45) | Final | W | 5 |
| 38 | 2018-03-27 | Mississippi State (60) | 60 | 75 | Penn State (85) | Final - 0:00 | W | 15 |
| 39 | 2018-03-29 | Penn State (52) | 82 | 66 | Utah (59) | Final | W | 16 |