Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-11-11 | Evansville (81) | 47 | 78 | Louisville (11) | Final | W | 31 |
| 2 | 2016-11-14 | William & Mary (99) | 58 | 91 | Louisville (11) | Final | W | 33 |
| 3 | 2016-11-17 | Long Beach State (114) | 56 | 88 | Louisville (11) | Final | W | 32 |
| 4 | 2016-11-23 | Louisville (11) | 68 | 62 | Old Dominion (109) | Final/OT | W | 6 |
| 5 | 2016-11-24 | Louisville (11) | 62 | 52 | Wichita State (34) | Final | W | 10 |
| 6 | 2016-11-25 | Louisville (11) | 63 | 66 | Baylor (25) | Final | L | -3 |
| 7 | 2016-11-30 | Purdue (20) | 64 | 71 | Louisville (19) | Final | W | 7 |
| 8 | 2016-12-03 | Louisville (19) | 79 | 70 | Grand Canyon (135) | Final | W | 9 |
| 9 | 2016-12-07 | Southern Illinois (123) | 51 | 74 | Louisville (11) | Final | W | 23 |
| 10 | 2016-12-10 | Texas Southern (145) | 71 | 102 | Louisville (11) | Final | W | 31 |
| 11 | 2016-12-17 | Eastern Kentucky (155) | 56 | 87 | Louisville (8) | Final | W | 31 |
| 12 | 2016-12-21 | Kentucky (6) | 70 | 73 | Louisville (7) | Final | W | 3 |
| 13 | 2016-12-28 | Virginia (12) | 61 | 53 | Louisville (5) | Final | L | -8 |
| 14 | 2016-12-31 | Louisville (5) | 77 | 62 | Indiana (25) | Final | W | 15 |
| 15 | 2017-01-04 | Louisville (7) | 70 | 77 | Notre Dame (19) | Final | L | -7 |
| 16 | 2017-01-07 | Louisville (7) | 65 | 50 | Georgia Tech (96) | Final | W | 15 |
| 17 | 2017-01-11 | Pittsburgh (42) | 80 | 85 | Louisville (10) | Final | W | 5 |
| 18 | 2017-01-14 | Duke (9) | 69 | 78 | Louisville (10) | Final | W | 9 |
| 19 | 2017-01-19 | Clemson (37) | 60 | 92 | Louisville (10) | Final | W | 32 |
| 20 | 2017-01-21 | Louisville (10) | 68 | 73 | Florida State (9) | Final | L | -5 |
| 21 | 2017-01-24 | Louisville (9) | 106 | 51 | Pittsburgh (53) | Final | W | 55 |
| 22 | 2017-01-29 | North Carolina State (70) | 60 | 85 | Louisville (9) | Final | W | 25 |
| 23 | 2017-02-04 | Louisville (4) | 90 | 67 | Boston College (140) | Final | W | 23 |
| 24 | 2017-02-06 | Louisville (4) | 55 | 71 | Virginia (9) | Final | L | -16 |
| 25 | 2017-02-11 | Miami (35) | 66 | 71 | Louisville (3) | Final | W | 5 |
| 26 | 2017-02-13 | Louisville (3) | 76 | 72 | Syracuse (44) | Final/OT | W | 4 |
| 27 | 2017-02-18 | Virginia Tech (33) | 90 | 94 | Louisville (5) | Final | W | 4 |
| 28 | 2017-02-22 | Louisville (4) | 63 | 74 | North Carolina (6) | Final | L | -11 |
| 29 | 2017-02-26 | Syracuse (50) | 68 | 88 | Louisville (4) | Final | W | 20 |
| 30 | 2017-03-01 | Louisville (7) | 81 | 88 | Wake Forest | Final | L | -7 |
| 31 | 2017-03-04 | Notre Dame (18) | 64 | 71 | Louisville (7) | Final | W | 7 |
| 32 | 2017-03-09 | Duke (15) | 81 | 77 | Louisville (7) | Final | L | -4 |
| 33 | 2017-03-17 | Jacksonville State (196) | 63 | 78 | Louisville (10) | Final | W | 15 |
| 34 | 2017-03-19 | Michigan (26) | 73 | 69 | Louisville (10) | Final | L | -4 |