Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-11-11 | Georgia (64) | 64 | 74 | Clemson (66) | Final | W | 10 |
| 2 | 2016-11-17 | Clemson (66) | 95 | 78 | Davidson (93) | Final | W | 17 |
| 3 | 2016-11-18 | Clemson (66) | 77 | 83 | Xavier (7) | Final | L | -6 |
| 4 | 2016-11-20 | Clemson (66) | 64 | 70 | Oklahoma (5) | Final | L | -6 |
| 5 | 2016-11-25 | High Point (151) | 74 | 83 | Clemson (66) | Final | W | 9 |
| 6 | 2016-11-30 | Nebraska (90) | 58 | 60 | Clemson (59) | Final | W | 2 |
| 7 | 2016-12-04 | Coppin State (349) | 43 | 85 | Clemson (59) | Final | W | 42 |
| 8 | 2016-12-10 | Mercer (161) | 47 | 90 | Clemson (54) | Final | W | 43 |
| 9 | 2016-12-13 | South Carolina State (328) | 65 | 93 | Clemson (45) | Final | W | 28 |
| 10 | 2016-12-18 | Clemson (45) | 67 | 54 | Alabama (121) | Final | W | 13 |
| 11 | 2016-12-21 | Clemson (43) | 62 | 60 | South Carolina (19) | Final | W | 2 |
| 12 | 2016-12-28 | UNC-Wilmington (45) | 73 | 87 | Clemson (35) | Final | W | 14 |
| 13 | 2016-12-31 | Clemson (35) | 73 | 68 | Wake Forest (40) | Final | W | 5 |
| 14 | 2017-01-03 | North Carolina (23) | 89 | 86 | Clemson (26) | Final/OT | L | -3 |
| 15 | 2017-01-07 | Clemson (26) | 70 | 75 | Notre Dame (19) | Final | L | -5 |
| 16 | 2017-01-12 | Clemson (27) | 63 | 75 | Georgia Tech (109) | Final | L | -12 |
| 17 | 2017-01-14 | Virginia (18) | 77 | 73 | Clemson (27) | Final | L | -4 |
| 18 | 2017-01-19 | Clemson (37) | 60 | 92 | Louisville (10) | Final | L | -32 |
| 19 | 2017-01-22 | Virginia Tech (32) | 82 | 81 | Clemson (37) | Final | L | -1 |
| 20 | 2017-01-28 | Clemson (41) | 67 | 60 | Pittsburgh (53) | Final | W | 7 |
| 21 | 2017-02-01 | Georgia Tech (59) | 62 | 74 | Clemson (39) | Final | W | 12 |
| 22 | 2017-02-05 | Clemson (39) | 61 | 109 | Florida State (15) | Final | L | -48 |
| 23 | 2017-02-07 | Syracuse (44) | 82 | 81 | Clemson (45) | Final | L | -1 |
| 24 | 2017-02-11 | Clemson (45) | 62 | 64 | Duke (18) | Final | L | -2 |
| 25 | 2017-02-14 | Wake Forest (40) | 83 | 95 | Clemson (48) | Final | W | 12 |
| 26 | 2017-02-18 | Clemson (48) | 65 | 71 | Miami (36) | Final | L | -6 |
| 27 | 2017-02-21 | Clemson (47) | 70 | 71 | Virginia Tech (36) | Final | L | -1 |
| 28 | 2017-02-25 | Florida State (15) | 76 | 74 | Clemson (47) | Final | L | -2 |
| 29 | 2017-03-01 | North Carolina State (82) | 74 | 78 | Clemson | Final | W | 4 |
| 30 | 2017-03-04 | Boston College (151) | 68 | 82 | Clemson (51) | Final | W | 14 |
| 31 | 2017-03-07 | North Carolina State (87) | 61 | 75 | Clemson (48) | Final | W | 14 |
| 32 | 2017-03-08 | Clemson (48) | 72 | 79 | Duke (15) | Final | L | -7 |
| 33 | 2017-03-14 | Oakland (99) | 74 | 69 | Clemson (50) | Final | L | -5 |