Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-01-02 | Lafayette (323) | 89 | 90 | Lehigh (276) | Final/OT | L | -1 |
| 2 | 2021-01-03 | Lehigh (276) | 70 | 82 | Lafayette (323) | Final | W | 12 |
| 3 | 2021-01-09 | Lafayette (323) | 83 | 60 | Bucknell (336) | Final | W | 23 |
| 4 | 2021-01-10 | Bucknell (336) | 76 | 87 | Lafayette (323) | Final | W | 11 |
| 5 | 2021-01-16 | Loyola-Maryland (325) | 75 | 77 | Lafayette (323) | Final | W | 2 |
| 6 | 2021-01-17 | Lafayette (323) | 72 | 70 | Loyola-Maryland (325) | Final | W | 2 |
| 7 | 2021-01-23 | Boston University (267) | 81 | 76 | Lafayette (323) | Final | L | -5 |
| 8 | 2021-01-24 | Boston University (267) | 64 | 61 | Lafayette (323) | Final | L | -3 |
| 9 | 2021-01-30 | Lafayette (323) | 0 | 0 | American (249) | Postponed | - | - |
| 10 | 2021-01-31 | American (249) | 0 | 0 | Lafayette (323) | Cancelled | - | - |
| 11 | 2021-02-06 | Lehigh (276) | 0 | 0 | Lafayette (323) | Postponed | - | - |
| 12 | 2021-02-07 | Lafayette (323) | 62 | 75 | Loyola-Maryland (325) | Final | L | -13 |
| 13 | 2021-02-07 | Lafayette (323) | 0 | 0 | Lehigh (276) | Postponed | - | - |
| 14 | 2021-02-08 | Loyola-Maryland (325) | 76 | 80 | Lafayette (323) | Final | W | 4 |
| 15 | 2021-02-13 | Lafayette | 0 | 0 | Navy | Cancelled | - | - |
| 16 | 2021-02-13 | Loyola-Maryland (325) | 94 | 97 | Lafayette (323) | Final/3OT | W | 3 |
| 17 | 2021-02-14 | Navy | 0 | 0 | Lafayette | Cancelled | - | - |
| 18 | 2021-02-14 | Lafayette (323) | 69 | 88 | Loyola-Maryland (325) | Final | L | -19 |
| 19 | 2021-02-20 | Bucknell (336) | 0 | 0 | Lafayette (323) | Cancelled | - | - |
| 20 | 2021-02-21 | Lafayette (323) | 0 | 0 | Bucknell (336) | Postponed | - | - |
| 21 | 2021-02-27 | Lehigh (276) | 69 | 75 | Lafayette (323) | Final | W | 6 |
| 22 | 2021-02-28 | Lafayette (323) | 71 | 70 | Lehigh (276) | Final | W | 1 |
| 23 | 2021-03-06 | Bucknell (336) | 92 | 84 | Lafayette (323) | Final | L | -8 |