Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-01-04 | Boston University (267) | 83 | 76 | Holy Cross (334) | Final | L | -7 |
| 2 | 2021-01-05 | Holy Cross (334) | 68 | 66 | Boston University (267) | Final | W | 2 |
| 3 | 2021-01-09 | Army (339) | 83 | 68 | Holy Cross (334) | Final | L | -15 |
| 4 | 2021-01-10 | Holy Cross (334) | 70 | 61 | Army (339) | Final | W | 9 |
| 5 | 2021-01-16 | Holy Cross (334) | 55 | 95 | Colgate (239) | Final | L | -40 |
| 6 | 2021-01-17 | Holy Cross (334) | 87 | 96 | Colgate (239) | Final | L | -9 |
| 7 | 2021-01-23 | Lehigh (276) | 75 | 72 | Holy Cross (334) | Final | L | -3 |
| 8 | 2021-01-24 | Lehigh (276) | 82 | 74 | Holy Cross (334) | Final | L | -8 |
| 9 | 2021-01-30 | Boston University (191) | 0 | 0 | Holy Cross (241) | Cancelled | - | - |
| 10 | 2021-01-30 | Colgate (239) | 74 | 63 | Holy Cross (334) | Final/OT | L | -11 |
| 11 | 2021-01-31 | Colgate (239) | 78 | 60 | Holy Cross (334) | Final | L | -18 |
| 12 | 2021-01-31 | Holy Cross (334) | 0 | 0 | Boston University (267) | Postponed | - | - |
| 13 | 2021-02-06 | Holy Cross (334) | 0 | 0 | Army (339) | Postponed | - | - |
| 14 | 2021-02-07 | Army (339) | 0 | 0 | Holy Cross (334) | Postponed | - | - |
| 15 | 2021-02-13 | Boston University (267) | 65 | 82 | Holy Cross (334) | Final | W | 17 |
| 16 | 2021-02-14 | Holy Cross (334) | 68 | 86 | Boston University (267) | Final | L | -18 |
| 17 | 2021-02-17 | Boston University (267) | 78 | 69 | Holy Cross (334) | Final | L | -9 |
| 18 | 2021-02-20 | Holy Cross (334) | 65 | 69 | Army (339) | Final | L | -4 |
| 19 | 2021-02-21 | Army (339) | 51 | 67 | Holy Cross (334) | Final | W | 16 |
| 20 | 2021-02-24 | Holy Cross (334) | 86 | 75 | Boston University (267) | Final | W | 11 |
| 21 | 2021-03-03 | Loyola-Maryland (325) | 0 | 0 | Holy Cross (334) | Cancelled | - | - |