Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2024-11-04 | Charleston (123) | 90 | 80 | Southern Illinois (150) | Final | L | -10 |
| 2 | 2024-11-08 | Missouri S&T | 64 | 86 | Southern Illinois (263) | Final | W | 22 |
| 3 | 2024-11-14 | Southern Illinois (277) | 78 | 85 | Oklahoma State (50) | Final | L | -7 |
| 4 | 2024-11-18 | North Dakota State (273) | 44 | 69 | Southern Illinois (201) | Final | W | 25 |
| 5 | 2024-11-22 | Southern Illinois (223) | 68 | 93 | Florida (9) | Final | L | -25 |
| 6 | 2024-11-25 | Southern Illinois (248) | 79 | 85 | Louisiana Tech (97) | Final (OT) | L | -6 |
| 7 | 2024-11-26 | Eastern Kentucky (194) | 77 | 72 | Southern Illinois (281) | Final | L | -5 |
| 8 | 2024-11-27 | Southern Illinois (275) | 81 | 54 | Florida Tech (281) | Final | W | 27 |
| 9 | 2024-12-03 | Bradley (52) | 83 | 60 | Southern Illinois (291) | Final | L | -23 |
| 10 | 2024-12-07 | Southern Indiana (246) | 70 | 73 | Southern Illinois (252) | Final | W | 3 |
| 11 | 2024-12-14 | Southern Illinois (204) | 65 | 60 | Austin Peay (272) | Final | W | 5 |
| 12 | 2024-12-21 | High Point (99) | 94 | 81 | Southern Illinois (226) | Final | L | -13 |
| 13 | 2024-12-29 | Southern Illinois (237) | 67 | 78 | Northern Iowa (101) | Final | L | -11 |
| 14 | 2025-01-01 | Evansville (294) | 68 | 53 | Southern Illinois (266) | Final | L | -15 |
| 15 | 2025-01-05 | Southern Illinois (286) | 54 | 85 | Illinois State (119) | Final | L | -31 |
| 16 | 2025-01-08 | Southern Illinois (287) | 86 | 90 | Belmont (106) | Final | L | -4 |
| 17 | 2025-01-11 | Missouri State (262) | 78 | 88 | Southern Illinois (274) | Final (OT) | W | 10 |
| 18 | 2025-01-15 | Southern Illinois (271) | 73 | 51 | Missouri State (261) | Final | W | 22 |
| 19 | 2025-01-18 | Northern Iowa (122) | 49 | 73 | Southern Illinois (223) | Final | W | 24 |
| 20 | 2025-01-22 | Murray State (126) | 74 | 64 | Southern Illinois (233) | Final | L | -10 |
| 21 | 2025-01-25 | Southern Illinois (211) | 89 | 85 | Illinois-Chicago (112) | Final | W | 4 |
| 22 | 2025-01-28 | Southern Illinois (203) | 79 | 75 | Valparaiso (207) | Final | W | 4 |
| 23 | 2025-02-01 | Drake (46) | 75 | 65 | Southern Illinois (201) | Final | L | -10 |
| 24 | 2025-02-05 | Southern Illinois (196) | 68 | 59 | Evansville (235) | Final | W | 9 |
| 25 | 2025-02-08 | Illinois-Chicago (135) | 67 | 79 | Southern Illinois (185) | Final | W | 12 |
| 26 | 2025-02-12 | Southern Illinois (188) | 64 | 78 | Bradley (69) | Final | L | -14 |
| 27 | 2025-02-15 | Belmont (111) | 73 | 68 | Southern Illinois (189) | Final | L | -5 |
| 28 | 2025-02-19 | Murray State (151) | 62 | 60 | Southern Illinois (194) | Final | L | -2 |
| 29 | 2025-02-22 | Valparaiso (207) | 83 | 79 | Southern Illinois (200) | Final | L | -4 |
| 30 | 2025-02-25 | Illinois State (94) | 79 | 88 | Southern Illinois (150) | Final | W | 9 |
| 31 | 2025-03-02 | Southern Illinois (197) | 77 | 95 | Indiana State (198) | Final | L | -18 |
| 32 | 2025-03-06 | Indiana State (207) | 85 | 86 | Southern Illinois (192) | Final | W | 1 |
| 33 | 2025-03-07 | Southern Illinois (196) | 53 | 70 | Drake (40) | Final | L | -17 |