Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | Southeast Missouri State (250) | 64 | 61 | South Florida (169) | Final | W | 3 |
| 2 | 2022-11-12 | Lyon College | 46 | 83 | Southeast Missouri State (250) | Final | W | 37 |
| 3 | 2022-11-16 | Southeast Missouri State (250) | 67 | 61 | Evansville (344) | Final | W | 6 |
| 4 | 2022-11-19 | Southeast Missouri State (226) | 60 | 73 | Bradley (113) | Final | L | -13 |
| 5 | 2022-11-22 | William Woods | 49 | 87 | Southeast Missouri State (250) | Final | W | 38 |
| 6 | 2022-11-26 | Boston University (274) | 52 | 63 | Southeast Missouri State (250) | Final | W | 11 |
| 7 | 2022-11-27 | Southeast Missouri State (250) | 71 | 73 | UC-Davis (176) | Final | L | -2 |
| 8 | 2022-11-28 | Southeast Missouri State (250) | 68 | 84 | Milwaukee (184) | Final | L | -16 |
| 9 | 2022-12-04 | Southeast Missouri State (250) | 89 | 96 | Missouri (38) | Final | L | -7 |
| 10 | 2022-12-07 | Purdue Fort Wayne (213) | 89 | 68 | Southeast Missouri State (250) | Final | L | -21 |
| 11 | 2022-12-14 | Southeast Missouri State (226) | 61 | 68 | Arkansas State (147) | Final | L | -7 |
| 12 | 2022-12-17 | Southeast Missouri State (250) | 75 | 106 | Iowa (43) | Final | L | -31 |
| 13 | 2022-12-21 | Southern Illinois (150) | 70 | 68 | Southeast Missouri State (226) | Final | L | -2 |
| 14 | 2022-12-29 | Southeast Missouri State (226) | 81 | 86 | Southern Indiana (352) | Final | L | -5 |
| 15 | 2022-12-31 | SIU-Edwardsville (241) | 73 | 82 | Southeast Missouri State (250) | Final | W | 9 |
| 16 | 2023-01-05 | Southeast Missouri State (250) | 82 | 87 | Tennessee-Martin (237) | Final | L | -5 |
| 17 | 2023-01-07 | Southeast Missouri State (250) | 74 | 68 | Little Rock (345) | Final | W | 6 |
| 18 | 2023-01-12 | Lindenwood (347) | 71 | 94 | Southeast Missouri State (250) | Final | W | 23 |
| 19 | 2023-01-14 | Southeast Missouri State (250) | 91 | 86 | Morehead State (212) | Final | W | 5 |
| 20 | 2023-01-19 | Tennessee-Martin (237) | 80 | 60 | Southeast Missouri State (250) | Final | L | -20 |
| 21 | 2023-01-21 | Tennessee Tech (288) | 77 | 84 | Southeast Missouri State (250) | Final | W | 7 |
| 22 | 2023-01-26 | Tennessee State (266) | 75 | 92 | Southeast Missouri State (250) | Final | W | 17 |
| 23 | 2023-01-28 | Southeast Missouri State (250) | 79 | 68 | Eastern Illinois (341) | Final | W | 11 |
| 24 | 2023-02-02 | Little Rock (345) | 98 | 99 | Southeast Missouri State (250) | Final | W | 1 |
| 25 | 2023-02-04 | Southeast Missouri State (250) | 80 | 82 | Tennessee Tech (288) | Final | L | -2 |
| 26 | 2023-02-09 | Southeast Missouri State (250) | 65 | 85 | Tennessee State (266) | Final | L | -20 |
| 27 | 2023-02-11 | Morehead State (233) | 65 | 59 | Southeast Missouri State (226) | Final | L | -6 |
| 28 | 2023-02-16 | Eastern Illinois (341) | 64 | 78 | Southeast Missouri State (250) | Final | W | 14 |
| 29 | 2023-02-18 | Southern Indiana (352) | 80 | 85 | Southeast Missouri State (226) | Final | W | 5 |
| 30 | 2023-02-23 | Southeast Missouri State (226) | 102 | 105 | Lindenwood (247) | Final/2OT | L | -3 |
| 31 | 2023-02-25 | Southeast Missouri State (263) | 78 | 93 | SIU-Edwardsville (239) | Final | L | -15 |
| 32 | 2023-03-01 | Lindenwood (247) | 65 | 84 | Southeast Missouri State (226) | Final | W | 19 |
| 33 | 2023-03-02 | Southeast Missouri State (226) | 91 | 83 | Tennessee State (165) | Final | W | 8 |
| 34 | 2023-03-03 | Southeast Missouri State (226) | 65 | 58 | Morehead State (233) | Final | W | 7 |
| 35 | 2023-03-04 | Southeast Missouri State (226) | 89 | 82 | Tennessee Tech (310) | Final/OT | W | 7 |
| 36 | 2023-03-14 | Southeast Missouri State | 71 | 75 | Texas A&M-Corpus Christi | Final | L | -4 |