Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | Penn (146) | 50 | 78 | Iona (84) | Final | L | -28 |
| 2 | 2022-11-11 | Penn (146) | 85 | 92 | Missouri (38) | Final | L | -7 |
| 3 | 2022-11-13 | Towson (147) | 80 | 74 | Penn (146) | Final | L | -6 |
| 4 | 2022-11-15 | Penn (146) | 64 | 59 | Drexel (217) | Final | W | 5 |
| 5 | 2022-11-18 | Penn (146) | 58 | 92 | West Virginia (42) | Final | L | -34 |
| 6 | 2022-11-22 | Penn (146) | 74 | 68 | Lafayette (298) | Final | W | 6 |
| 7 | 2022-11-25 | Hartford (361) | 55 | 75 | Penn (146) | Final | W | 20 |
| 8 | 2022-11-26 | Colgate (124) | 69 | 81 | Penn (146) | Final | W | 12 |
| 9 | 2022-11-27 | Delaware (220) | 73 | 86 | Penn (146) | Final | W | 13 |
| 10 | 2022-11-30 | Saint Joseph's (99) | 85 | 80 | Penn (131) | Final/OT | L | -5 |
| 11 | 2022-12-03 | La Salle (237) | 84 | 81 | Penn (131) | Final/OT | L | -3 |
| 12 | 2022-12-07 | Penn (146) | 59 | 70 | Villanova (93) | Final | L | -11 |
| 13 | 2022-12-10 | Temple (108) | 57 | 77 | Penn (146) | Final | W | 20 |
| 14 | 2022-12-28 | Wilkes | 61 | 93 | Penn (131) | Final | W | 32 |
| 15 | 2023-01-02 | Penn (146) | 76 | 68 | Brown (187) | Final | W | 8 |
| 16 | 2023-01-06 | Penn (146) | 69 | 88 | Cornell (140) | Final | L | -19 |
| 17 | 2023-01-07 | Penn (146) | 84 | 55 | Columbia (340) | Final | W | 29 |
| 18 | 2023-01-14 | Penn (146) | 71 | 75 | Dartmouth (281) | Final | L | -4 |
| 19 | 2023-01-16 | Princeton (137) | 72 | 60 | Penn (146) | Final | L | -12 |
| 20 | 2023-01-21 | Penn (146) | 63 | 70 | Yale (90) | Final | L | -7 |
| 21 | 2023-01-23 | Penn (146) | 76 | 52 | Hartford (361) | Final | W | 24 |
| 22 | 2023-01-28 | Harvard (183) | 68 | 83 | Penn (146) | Final | W | 15 |
| 23 | 2023-02-03 | Columbia (340) | 65 | 74 | Penn (146) | Final | W | 9 |
| 24 | 2023-02-04 | Cornell (140) | 86 | 92 | Penn (146) | Final | W | 6 |
| 25 | 2023-02-11 | Penn (131) | 80 | 72 | Harvard (181) | Final | W | 8 |
| 26 | 2023-02-17 | Yale (90) | 64 | 66 | Penn (146) | Final | W | 2 |
| 27 | 2023-02-18 | Brown (295) | 69 | 90 | Penn (131) | Final | W | 21 |
| 28 | 2023-02-25 | Dartmouth (285) | 79 | 89 | Penn (140) | Final | W | 10 |
| 29 | 2023-03-04 | Penn (131) | 69 | 77 | Princeton (271) | Final/OT | L | -8 |
| 30 | 2023-03-11 | Penn (147) | 70 | 77 | Princeton (124) | Final | L | -7 |