Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-10 | Radford (188) | 76 | 79 | Notre Dame (199) | Final | W | 3 |
| 2 | 2022-11-13 | Youngstown State (119) | 81 | 88 | Notre Dame (199) | Final | W | 7 |
| 3 | 2022-11-16 | Southern Indiana (265) | 70 | 82 | Notre Dame (199) | Final | W | 12 |
| 4 | 2022-11-18 | Lipscomb (186) | 65 | 66 | Notre Dame (199) | Final | W | 1 |
| 5 | 2022-11-22 | Bowling Green (290) | 66 | 82 | Notre Dame (199) | Final | W | 16 |
| 6 | 2022-11-25 | Notre Dame (199) | 51 | 63 | St. Bonaventure (171) | Final | L | -12 |
| 7 | 2022-11-30 | Michigan State (10) | 52 | 70 | Notre Dame (101) | Final | W | 18 |
| 8 | 2022-12-03 | Syracuse (84) | 62 | 61 | Notre Dame (101) | Final | L | -1 |
| 9 | 2022-12-07 | Boston University (274) | 75 | 81 | Notre Dame (199) | Final | W | 6 |
| 10 | 2022-12-11 | Marquette (14) | 79 | 64 | Notre Dame (199) | Final | L | -15 |
| 11 | 2022-12-21 | Notre Dame (101) | 72 | 73 | Florida State (64) | Final | L | -1 |
| 12 | 2022-12-27 | Jacksonville (233) | 43 | 59 | Notre Dame (199) | Final | W | 16 |
| 13 | 2022-12-30 | Miami (16) | 76 | 65 | Notre Dame (199) | Final | L | -11 |
| 14 | 2023-01-03 | Notre Dame (199) | 63 | 70 | Boston College (142) | Final | L | -7 |
| 15 | 2023-01-07 | Notre Dame (199) | 64 | 81 | North Carolina (47) | Final | L | -17 |
| 16 | 2023-01-10 | Georgia Tech (168) | 72 | 73 | Notre Dame (199) | Final | W | 1 |
| 17 | 2023-01-14 | Notre Dame (199) | 73 | 78 | Syracuse (87) | Final | L | -5 |
| 18 | 2023-01-17 | Florida State (209) | 84 | 71 | Notre Dame (199) | Final | L | -13 |
| 19 | 2023-01-21 | Boston College (142) | 84 | 72 | Notre Dame (199) | Final | L | -12 |
| 20 | 2023-01-24 | Notre Dame (199) | 82 | 85 | North Carolina State (26) | Final | L | -3 |
| 21 | 2023-01-28 | Louisville (287) | 62 | 76 | Notre Dame (199) | Final | W | 14 |
| 22 | 2023-02-04 | Wake Forest (59) | 81 | 64 | Notre Dame (199) | Final | L | -17 |
| 23 | 2023-02-08 | Notre Dame (199) | 68 | 70 | Georgia Tech (168) | Final | L | -2 |
| 24 | 2023-02-11 | Virginia Tech (56) | 93 | 87 | Notre Dame (101) | Final | L | -6 |
| 25 | 2023-02-14 | Notre Dame (199) | 64 | 68 | Duke (25) | Final | L | -4 |
| 26 | 2023-02-18 | Notre Dame (101) | 55 | 57 | Virginia (14) | Final | L | -2 |
| 27 | 2023-02-22 | North Carolina (22) | 63 | 59 | Notre Dame (101) | Final | L | -4 |
| 28 | 2023-02-25 | Notre Dame (172) | 58 | 66 | Wake Forest (65) | Final | L | -8 |
| 29 | 2023-03-01 | Pittsburgh (108) | 81 | 88 | Notre Dame (101) | Final | W | 7 |
| 30 | 2023-03-04 | Notre Dame (101) | 64 | 87 | Clemson (36) | Final | L | -23 |
| 31 | 2023-03-07 | Notre Dame (162) | 64 | 67 | Virginia Tech (68) | Final | L | -3 |