Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2024-11-04 | Monmouth (176) | 57 | 81 | Michigan State (10) | Final | W | 24 |
| 2 | 2024-11-07 | Niagara (342) | 60 | 96 | Michigan State (10) | Final | W | 36 |
| 3 | 2024-11-12 | Michigan State (116) | 69 | 77 | Kansas (13) | Final | L | -8 |
| 4 | 2024-11-16 | Bowling Green (315) | 72 | 86 | Michigan State (105) | Final | W | 14 |
| 5 | 2024-11-19 | Samford (154) | 75 | 83 | Michigan State (64) | Final | W | 8 |
| 6 | 2024-11-25 | Colorado (82) | 56 | 72 | Michigan State (54) | Final | W | 16 |
| 7 | 2024-11-26 | Memphis (6) | 71 | 63 | Michigan State (56) | Final | L | -8 |
| 8 | 2024-11-27 | Michigan State (41) | 94 | 91 | North Carolina (55) | Final (OT) | W | 3 |
| 9 | 2024-12-04 | Michigan State (38) | 90 | 72 | Minnesota (122) | Final | W | 18 |
| 10 | 2024-12-07 | Nebraska (60) | 52 | 89 | Michigan State (23) | Final | W | 37 |
| 11 | 2024-12-17 | Michigan State (19) | 77 | 58 | Oakland (235) | Final | W | 19 |
| 12 | 2024-12-21 | Florida Atlantic (109) | 69 | 86 | Michigan State (17) | Final | W | 17 |
| 13 | 2024-12-30 | Western Michigan (316) | 62 | 80 | Michigan State (17) | Final | W | 18 |
| 14 | 2025-01-03 | Michigan State (14) | 69 | 62 | Ohio State (44) | Final | W | 7 |
| 15 | 2025-01-09 | Washington (89) | 54 | 88 | Michigan State (13) | Final | W | 34 |
| 16 | 2025-01-12 | Michigan State (11) | 78 | 68 | Northwestern (63) | Final | W | 10 |
| 17 | 2025-01-15 | Penn State (48) | 85 | 90 | Michigan State (13) | Final | W | 5 |
| 18 | 2025-01-19 | Illinois (16) | 78 | 80 | Michigan State (8) | Final | W | 2 |
| 19 | 2025-01-25 | Michigan State (8) | 81 | 74 | Rutgers (83) | Final | W | 7 |
| 20 | 2025-01-28 | Minnesota (81) | 51 | 73 | Michigan State (8) | Final | W | 22 |
| 21 | 2025-02-01 | Michigan State (11) | 64 | 70 | USC (53) | Final | L | -6 |
| 22 | 2025-02-04 | Michigan State (15) | 61 | 63 | UCLA (31) | Final | L | -2 |
| 23 | 2025-02-08 | Oregon (35) | 74 | 86 | Michigan State (11) | Final | W | 12 |
| 24 | 2025-02-11 | Indiana (51) | 71 | 67 | Michigan State (17) | Final | L | -4 |
| 25 | 2025-02-15 | Michigan State (15) | 79 | 65 | Illinois (26) | Final | W | 14 |
| 26 | 2025-02-18 | Purdue (13) | 66 | 75 | Michigan State (12) | Final | W | 9 |
| 27 | 2025-02-21 | Michigan State (9) | 75 | 62 | Michigan (16) | Final | W | 13 |
| 28 | 2025-02-26 | Michigan State (7) | 58 | 55 | Maryland (15) | Final | W | 3 |
| 29 | 2025-03-02 | Wisconsin (13) | 62 | 71 | Michigan State (7) | Final | W | 9 |
| 30 | 2025-03-06 | Michigan State (7) | 91 | 84 | Iowa (73) | Final | W | 7 |
| 31 | 2025-03-09 | Michigan (23) | 62 | 79 | Michigan State (7) | Final | W | 17 |
| 32 | 2025-03-14 | Oregon (22) | 64 | 74 | Michigan State (7) | Final | W | 10 |
| 33 | 2025-03-15 | Wisconsin | 77 | 74 | Michigan State | Final | L | -3 |
| 34 | 2025-03-21 | Bryant (154) | 62 | 87 | Michigan State (7) | Final | W | 25 |
| 35 | 2025-03-23 | New Mexico (38) | 63 | 71 | Michigan State (7) | Final | W | 8 |
| 36 | 2025-03-28 | Ole Miss (16) | 70 | 73 | Michigan State (7) | Final | W | 3 |
| 37 | 2025-03-30 | Michigan State (7) | 64 | 70 | Auburn (1) | Final | L | -6 |