Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2025-11-03 | New Hampshire (351) | 38 | 88 | Clemson (25) | Final | W | 50 |
| 2 | 2025-11-07 | Gardner-Webb (269) | 59 | 97 | Clemson (25) | Final | W | 38 |
| 3 | 2025-11-11 | Morehead State (298) | 56 | 83 | Clemson (25) | Final | W | 27 |
| 4 | 2025-11-15 | Clemson (25) | 74 | 79 | Georgetown (91) | Final | L | -5 |
| 5 | 2025-11-17 | North Alabama (141) | 61 | 81 | Clemson (25) | Final | W | 20 |
| 6 | 2025-11-21 | West Virginia (49) | 67 | 70 | Clemson (25) | Final | W | 3 |
| 7 | 2025-11-23 | Clemson (25) | 97 | 94 | Georgia (34) | Final/OT | W | 3 |
| 8 | 2025-11-28 | Alabama A&M (355) | Clemson (25) | Scheduled – 7:00 PM | – | – | ||
| 9 | 2025-12-03 | Clemson | Alabama | Scheduled – 6:15 PM | – | – | ||
| 10 | 2025-12-09 | Clemson | BYU | Scheduled – 6:30 PM | – | – | ||
| 11 | 2025-12-13 | Mercer | Clemson | Scheduled – 3:00 PM | – | – | ||
| 12 | 2025-12-16 | South Carolina | Clemson | Scheduled – 7:00 PM | – | – | ||
| 13 | 2025-12-21 | Cincinnati | Clemson | Scheduled – 3:00 PM | – | – | ||
| 14 | 2025-12-31 | Clemson | Syracuse | Scheduled – 2:00 PM | – | – | ||
| 15 | 2026-01-03 | Clemson | Pittsburgh | Scheduled – 12:00 PM | – | – | ||
| 16 | 2026-01-07 | SMU | Clemson | Scheduled – 9:00 PM | – | – | ||
| 17 | 2026-01-10 | Clemson | Notre Dame | Scheduled – 6:00 PM | – | – | ||
| 18 | 2026-01-13 | Boston College | Clemson | Scheduled – 7:00 PM | – | – | ||
| 19 | 2026-01-17 | Miami | Clemson | Scheduled – 2:15 PM | – | – | ||
| 20 | 2026-01-20 | North Carolina State | Clemson | Scheduled – 7:00 PM | – | – | ||
| 21 | 2026-01-24 | Clemson | Georgia Tech | Scheduled – 12:00 PM | – | – | ||
| 22 | 2026-01-31 | Pittsburgh | Clemson | Scheduled – 12:00 PM | – | – | ||
| 23 | 2026-02-04 | Clemson | Stanford | Scheduled – 7:00 PM | – | – | ||
| 24 | 2026-02-07 | Clemson | California | Scheduled – 5:00 PM | – | – | ||
| 25 | 2026-02-11 | Virginia Tech | Clemson | Scheduled – 7:00 PM | – | – | ||
| 26 | 2026-02-14 | Clemson | Duke | Scheduled – 12:00 PM | – | – | ||
| 27 | 2026-02-18 | Clemson | Wake Forest | Scheduled – 7:00 PM | – | – | ||
| 28 | 2026-02-21 | Florida State | Clemson | Scheduled – 12:00 PM | – | – | ||
| 29 | 2026-02-28 | Louisville | Clemson | Scheduled – 12:00 AM | – | – | ||
| 30 | 2026-03-03 | Clemson | North Carolina | Scheduled – 7:00 PM | – | – | ||
| 31 | 2026-03-07 | Georgia Tech | Clemson | Scheduled – 12:00 PM | – | – |