NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-27 | Alabama A&M (196) | 0 | 0 | Southern Miss (197) | Cancelled | - | - |
| 2 | 2020-11-28 | Southeastern Louisiana (349) | 0 | 0 | Southern Miss (197) | Cancelled | - | - |
| 3 | 2020-12-05 | McNeese (80) | 0 | 0 | Southern Miss (197) | Cancelled | - | - |
| 4 | 2020-12-08 | Nicholls State (273) | 0 | 0 | Southern Miss (197) | Cancelled | - | - |
| 5 | 2020-12-12 | Mississippi State (51) | 0 | 0 | Southern Miss (197) | Cancelled | - | - |
| 6 | 2020-12-17 | Southern Miss (197) | 0 | 0 | Alabama (21) | Cancelled | - | - |
| 7 | 2020-12-18 | Nicholls State (273) | 50 | 63 | Southern Miss (197) | Final | W | 13 |
| 8 | 2020-12-19 | William Carey | 50 | 57 | Southern Miss (197) | Final | W | 7 |
| 9 | 2021-01-01 | Southern Miss (197) | 65 | 83 | UTEP (257) | Final | L | -18 |
| 10 | 2021-01-02 | Southern Miss (197) | 72 | 74 | UTEP (257) | Final | L | -2 |
| 11 | 2021-01-08 | UAB (217) | 85 | 63 | Southern Miss (197) | Final | L | -22 |
| 12 | 2021-01-09 | UAB (217) | 84 | 65 | Southern Miss (197) | Final | L | -19 |
| 13 | 2021-01-15 | Southern Miss (197) | 58 | 78 | Middle Tennessee (164) | Final | L | -20 |
| 14 | 2021-01-16 | Southern Miss (197) | 69 | 61 | Middle Tennessee (164) | Final | W | 8 |
| 15 | 2021-01-22 | UTSA (120) | 64 | 88 | Southern Miss (197) | Final | W | 24 |
| 16 | 2021-01-23 | UTSA (120) | 66 | 73 | Southern Miss (197) | Final | W | 7 |
| 17 | 2021-01-28 | Southern Miss (197) | 60 | 77 | Louisiana Tech (68) | Final | L | -17 |
| 18 | 2021-01-30 | Louisiana Tech (68) | 44 | 57 | Southern Miss (197) | Final | W | 13 |
| 19 | 2021-02-05 | Rice (58) | 0 | 0 | Southern Miss (197) | Cancelled | - | - |
| 20 | 2021-02-06 | Rice (58) | 0 | 0 | Southern Miss (197) | Postponed | - | - |
| 21 | 2021-02-12 | Southern Miss (197) | 55 | 76 | North Texas (115) | Final | L | -21 |
| 22 | 2021-02-13 | Southern Miss (197) | 64 | 72 | North Texas (115) | Final | L | -8 |
| 23 | 2021-02-19 | Florida International (139) | 59 | 58 | Southern Miss (197) | Final/OT | L | -1 |
| 24 | 2021-02-20 | Florida International (139) | 60 | 76 | Southern Miss (197) | Final | W | 16 |
| 25 | 2021-02-26 | Southern Miss (197) | 63 | 78 | Florida Atlantic (205) | Final | L | -15 |
| 26 | 2021-02-27 | Southern Miss (197) | 61 | 86 | Florida Atlantic (205) | Final | L | -25 |
| 27 | 2021-03-10 | Southern Miss (243) | 75 | 85 | Florida International (205) | Final | L | -10 |