NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Santa Clara (86) | 0 | 0 | Cal State-Bakersfield (326) | Cancelled | - | - |
| 2 | 2020-12-11 | Santa Clara (191) | 59 | 49 | Cal State-Bakersfield (112) | Final | W | 10 |
| 3 | 2020-12-14 | Santa Clara (86) | 56 | 57 | Cal Poly (350) | Final | L | -1 |
| 4 | 2020-12-15 | Santa Clara (86) | 59 | 70 | Cal Poly (350) | Final | L | -11 |
| 5 | 2020-12-18 | Santa Clara (86) | 82 | 60 | UC-Santa Barbara (161) | Final | W | 22 |
| 6 | 2020-12-19 | Santa Clara (86) | 73 | 51 | UC-Santa Barbara (161) | Final | W | 22 |
| 7 | 2020-12-23 | Santa Clara (86) | 54 | 48 | UC-Riverside (267) | Final | W | 6 |
| 8 | 2020-12-28 | Santa Clara (143) | 51 | 49 | San Diego (214) | Final | W | 2 |
| 9 | 2020-12-30 | Santa Clara (86) | 50 | 76 | BYU (45) | Final | L | -26 |
| 10 | 2021-01-02 | Loyola Marymount (117) | 66 | 57 | Santa Clara (86) | Final | L | -9 |
| 11 | 2021-01-04 | Pepperdine (146) | 0 | 0 | Santa Clara (86) | Postponed | - | - |
| 12 | 2021-01-07 | Santa Clara (86) | 77 | 59 | Saint Mary's (223) | Final | W | 18 |
| 13 | 2021-01-09 | Santa Clara (86) | 77 | 74 | Pacific (227) | Final | W | 3 |
| 14 | 2021-01-14 | Gonzaga (26) | 71 | 52 | Santa Clara (139) | Final | L | -19 |
| 15 | 2021-01-16 | Portland (138) | 65 | 84 | Santa Clara (86) | Final | W | 19 |
| 16 | 2021-01-23 | San Francisco (152) | 67 | 54 | Santa Clara (86) | Final | L | -13 |
| 17 | 2021-01-30 | Santa Clara (141) | Loyola Marymount (187) | Cancelled | - | - | ||
| 18 | 2021-01-30 | Santa Clara (86) | 68 | 64 | Pepperdine (146) | Final | W | 4 |
| 19 | 2021-01-31 | Santa Clara (86) | 66 | 57 | Pepperdine (146) | Final | W | 9 |
| 20 | 2021-02-04 | Pacific (227) | 86 | 62 | Santa Clara (86) | Final | L | -24 |
| 21 | 2021-02-06 | Saint Mary's (223) | 64 | 75 | Santa Clara (86) | Final | W | 11 |
| 22 | 2021-02-11 | Santa Clara (86) | 77 | 76 | Portland (138) | Final | W | 1 |
| 23 | 2021-02-13 | Santa Clara (86) | 50 | 67 | Gonzaga (65) | Final | L | -17 |
| 24 | 2021-02-16 | Santa Clara (140) | 79 | 65 | Loyola Marymount (226) | Final | W | 14 |
| 25 | 2021-02-20 | Santa Clara (86) | 64 | 87 | San Francisco (152) | Final | L | -23 |
| 26 | 2021-02-25 | BYU (45) | 66 | 63 | Santa Clara (86) | Final | L | -3 |
| 27 | 2021-02-27 | San Diego (260) | 0 | 0 | Santa Clara (86) | Cancelled | - | - |
| 28 | 2021-03-06 | Loyola Marymount (117) | 68 | 83 | Santa Clara (86) | Final | W | 15 |
| 29 | 2021-03-08 | Santa Clara (147) | 62 | 72 | Gonzaga (17) | Final | L | -10 |