NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | East Carolina (106) | 81 | 89 | Towson (199) | Final | L | -8 |
| 2 | 2020-11-29 | East Carolina (106) | 54 | 51 | Virginia (38) | Final | W | 3 |
| 3 | 2020-12-03 | Georgia (30) | 66 | 45 | East Carolina (106) | Final | L | -21 |
| 4 | 2020-12-05 | East Carolina (106) | 47 | 72 | Duke (8) | Final | L | -25 |
| 5 | 2020-12-09 | Virginia Commonwealth (207) | 55 | 58 | East Carolina (268) | Final | W | 3 |
| 6 | 2020-12-16 | East Carolina (106) | 50 | 46 | SMU (209) | Final | W | 4 |
| 7 | 2020-12-20 | East Carolina (217) | 74 | 67 | Cincinnati (249) | Final | W | 7 |
| 8 | 2020-12-22 | Tulane (211) | 64 | 72 | East Carolina (106) | Final | W | 8 |
| 9 | 2021-01-02 | East Carolina (106) | 58 | 71 | South Florida (72) | Final | L | -13 |
| 10 | 2021-01-06 | Temple (151) | 66 | 57 | East Carolina (106) | Final | L | -9 |
| 11 | 2021-01-09 | East Carolina (106) | 0 | 0 | Wichita State (266) | Cancelled | - | - |
| 12 | 2021-01-13 | Central Florida (55) | 58 | 51 | East Carolina (130) | Final | L | -7 |
| 13 | 2021-01-16 | Houston (180) | 66 | 56 | East Carolina (106) | Final | L | -10 |
| 14 | 2021-01-20 | East Carolina (106) | 54 | 68 | Tulsa (140) | Final | L | -14 |
| 15 | 2021-01-23 | South Florida (72) | 0 | 0 | East Carolina (106) | Postponed | - | - |
| 16 | 2021-01-27 | East Carolina (106) | 47 | 52 | Central Florida (150) | Final | L | -5 |
| 17 | 2021-01-30 | Tulsa (140) | 68 | 59 | East Carolina (106) | Final | L | -9 |
| 18 | 2021-02-06 | East Carolina (106) | 67 | 53 | Memphis (239) | Final | W | 14 |
| 19 | 2021-02-10 | SMU (286) | East Carolina (165) | Cancelled | - | - | ||
| 20 | 2021-02-10 | South Florida (17) | 0 | 0 | East Carolina (165) | Postponed | - | - |
| 21 | 2021-02-13 | East Carolina (106) | 57 | 58 | Temple (151) | Final | L | -1 |
| 22 | 2021-02-17 | East Carolina (106) | 0 | 0 | Houston (180) | Cancelled | - | - |
| 23 | 2021-02-20 | Wichita State (266) | 59 | 74 | East Carolina (106) | Final | W | 15 |
| 24 | 2021-02-24 | Cincinnati (122) | 76 | 61 | East Carolina (106) | Final | L | -15 |
| 25 | 2021-02-27 | Memphis (239) | 62 | 81 | East Carolina (106) | Final | W | 19 |
| 26 | 2021-03-02 | East Carolina (106) | 60 | 77 | Tulane (211) | Final | L | -17 |
| 27 | 2021-03-09 | East Carolina (172) | 63 | 73 | Houston (42) | Final | L | -10 |