NCAA Women’s Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-28 | Texas A&M (21) | 93 | 91 | DePaul (18) | Final | L | -2 |
| 2 | 2020-11-30 | Chicago State (350) | 66 | 128 | DePaul (18) | Final | W | 62 |
| 3 | 2020-12-04 | DePaul (104) | Villanova (12) | 12/4 – 7:00 PM EST | – | – | ||
| 4 | 2020-12-04 | Louisville (20) | 116 | 75 | DePaul (104) | Final | L | -41 |
| 5 | 2020-12-06 | Xavier (95) | 0 | 0 | DePaul (104) | Postponed | – | – |
| 6 | 2020-12-09 | DePaul (138) | 0 | 0 | Kent State (283) | Canceled | – | – |
| 7 | 2020-12-13 | Loyola-Chicago (127) | 67 | 76 | DePaul (138) | Final | W | 9 |
| 8 | 2020-12-16 | Kentucky (2) | 82 | 86 | DePaul (87) | Final | W | 4 |
| 9 | 2020-12-19 | Georgetown (171) | 54 | 72 | DePaul (87) | Final | W | 18 |
| 10 | 2020-12-22 | DePaul (87) | 90 | 81 | Creighton (199) | Final | W | 9 |
| 11 | 2020-12-29 | DePaul (41) | 52 | 75 | Connecticut (13) | Final | L | -23 |
| 12 | 2021-01-03 | DePaul (33) | 0 | 0 | Marquette (30) | Postponed | – | – |
| 13 | 2021-01-04 | Villanova (32) | 82 | 94 | DePaul (33) | Final | W | 12 |
| 14 | 2021-01-07 | DePaul (24) | 0 | 0 | Butler (329) | 1/7 – 2:00 PM EST | – | – |
| 15 | 2021-01-13 | St. John’s (173) | 84 | 101 | DePaul (29) | Final | W | 17 |
| 16 | 2021-01-16 | DePaul (29) | 78 | 54 | Georgetown (184) | Final | W | 24 |
| 17 | 2021-01-20 | DePaul (30) | 0 | 0 | Villanova (41) | Postponed | – | – |
| 18 | 2021-01-21 | DePaul (30) | 80 | 66 | Butler (307) | Final | W | 14 |
| 19 | 2021-01-23 | Providence (173) | 0 | 0 | DePaul (30) | Postponed | – | – |
| 20 | 2021-01-25 | DePaul (30) | 0 | 0 | Xavier (164) | Postponed | – | – |
| 21 | 2021-01-31 | Connecticut (3) | 100 | 67 | DePaul (30) | Final | L | -33 |
| 22 | 2021-02-04 | DePaul (37) | 0 | 0 | Seton Hall (61) | Postponed | – | – |
| 23 | 2021-02-07 | DePaul (37) | 87 | 82 | Marquette (41) | Final | W | 5 |
| 24 | 2021-02-10 | DePaul (31) | 81 | 73 | St. John’s (187) | Final | W | 8 |
| 25 | 2021-02-12 | Villanova (43) | 0 | 0 | DePaul (31) | Postponed | – | – |
| 26 | 2021-02-15 | Seton Hall (64) | 76 | 82 | DePaul (31) | Final | W | 6 |
| 27 | 2021-02-17 | Xavier (182) | 75 | 83 | DePaul (27) | Final | W | 8 |
| 28 | 2021-02-20 | Creighton (136) | 83 | 72 | DePaul (27) | Final | L | -11 |
| 29 | 2021-02-24 | Marquette (41) | 85 | 71 | DePaul (34) | Final | L | -14 |
| 30 | 2021-02-27 | DePaul (34) | 75 | 49 | Providence (184) | Final | W | 26 |
| 31 | 2021-03-01 | Butler (299) | 86 | 81 | DePaul (34) | Final | L | -5 |
| 32 | 2021-03-06 | Villanova (59) | 78 | 72 | DePaul (47) | Final/OT | L | -6 |
| 33 | 2021-03-19 | Saint Louis (79) | 74 | 72 | DePaul (52) | Final | L | -2 |
| 34 | 2021-03-20 | DePaul (52) | 91 | 100 | Drake (71) | Final | L | -9 |