Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Cal Poly | 28 | San Diego | 17 | Final | L | -11 |
| 2 | 2021-09-11 | UC-Davis | 53 | San Diego | 7 | Final | L | -46 |
| 3 | 2021-09-18 | San Diego | 10 | Montana State | 52 | Final | L | -42 |
| 4 | 2021-09-25 | San Diego | 16 | Davidson | 28 | Final | L | -12 |
| 5 | 2021-10-02 | St. Thomas | 24 | San Diego | 27 | Final | W | 3 |
| 6 | 2021-10-09 | San Diego | 52 | Butler | 21 | Final | W | 31 |
| 7 | 2021-10-16 | Drake | 10 | San Diego | 13 | Final | W | 3 |
| 8 | 2021-10-23 | San Diego | 69 | Presbyterian | 28 | Final | W | 41 |
| 9 | 2021-10-30 | Valparaiso | 14 | San Diego | 21 | Final | W | 7 |
| 10 | 2021-11-06 | Morehead State | 3 | San Diego | 10 | Final | W | 7 |
| 11 | 2021-11-20 | San Diego | 41 | Stetson | 16 | Final | W | 25 |