Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Lafayette | 14 | Air Force | 35 | Final | L | -21 |
| 2 | 2021-09-11 | Lafayette | 3 | William & Mary | 24 | Final | L | -21 |
| 3 | 2021-09-18 | New Hampshire | 19 | Lafayette | 13 | Final | L | -6 |
| 4 | 2021-09-25 | Penn | 14 | Lafayette | 24 | Final | W | 10 |
| 5 | 2021-10-02 | Fordham | 42 | Lafayette | 41 | Final | L | -1 |
| 6 | 2021-10-09 | Bucknell | 0 | Lafayette | 27 | Final | W | 27 |
| 7 | 2021-10-16 | Lafayette | 3 | Harvard | 30 | Final | L | -27 |
| 8 | 2021-10-30 | Lafayette | 24 | Georgetown | 23 | Final | W | 1 |
| 9 | 2021-11-06 | Lafayette | 10 | Holy Cross | 35 | Final | L | -25 |
| 10 | 2021-11-13 | Colgate | 20 | Lafayette | 13 | Final | L | -7 |
| 11 | 2021-11-20 | Lafayette | 10 | Lehigh | 17 | Final | L | -7 |