Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | UNLV (110) | 21 | USC (13) | 43 | Final | W | 22 |
| 2 | 2018-09-08 | USC (13) | 3 | Stanford (16) | 17 | Final | L | -14 |
| 3 | 2018-09-15 | USC (13) | 14 | Texas (56) | 37 | Final | L | -23 |
| 4 | 2018-09-21 | Washington State | 36 | USC | 39 | Final | W | 3 |
| 5 | 2018-09-29 | USC (57) | 24 | Arizona (83) | 20 | Final | W | 4 |
| 6 | 2018-10-13 | Colorado (18) | 20 | USC (52) | 31 | Final | W | 11 |
| 7 | 2018-10-20 | USC (38) | 28 | Utah (40) | 41 | Final | L | -13 |
| 8 | 2018-10-27 | Arizona State (68) | 38 | USC (51) | 35 | Final | L | -3 |
| 9 | 2018-11-03 | USC (59) | 38 | Oregon State (111) | 21 | Final | W | 17 |
| 10 | 2018-11-10 | California (75) | 15 | USC (57) | 14 | Final | L | -1 |
| 11 | 2018-11-17 | USC (63) | 27 | UCLA (100) | 34 | Final | L | -7 |
| 12 | 2018-11-24 | Notre Dame (3) | 24 | USC (75) | 17 | Final | L | -7 |