Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Michigan (27) | 17 | Notre Dame (10) | 24 | Final | W | 7 |
| 2 | 2018-09-08 | Ball State (147) | 16 | Notre Dame (10) | 24 | Final | W | 8 |
| 3 | 2018-09-15 | Vanderbilt (88) | 17 | Notre Dame (10) | 22 | Final | W | 5 |
| 4 | 2018-09-22 | Notre Dame (10) | 56 | Wake Forest (34) | 27 | Final | W | 29 |
| 5 | 2018-09-29 | Stanford (8) | 17 | Notre Dame (6) | 38 | Final | W | 21 |
| 6 | 2018-10-06 | Notre Dame (3) | 45 | Virginia Tech (42) | 23 | Final | W | 22 |
| 7 | 2018-10-13 | Pittsburgh (73) | 14 | Notre Dame (4) | 19 | Final | W | 5 |
| 8 | 2018-10-27 | Notre Dame (3) | 44 | Navy (110) | 22 | Final | W | 22 |
| 9 | 2018-11-03 | Notre Dame (3) | 31 | Northwestern (42) | 21 | Final | W | 10 |
| 10 | 2018-11-10 | Florida State (84) | 13 | Notre Dame (3) | 42 | Final | W | 29 |
| 11 | 2018-11-17 | Syracuse (18) | 3 | Notre Dame (3) | 36 | Final | W | 33 |
| 12 | 2018-11-24 | Notre Dame (3) | 24 | USC (75) | 17 | Final | W | 7 |
| 13 | 2018-12-29 | Notre Dame (3) | 3 | Clemson (2) | 30 | Final | L | -27 |