Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-05 | Florida A&M | 3 | South Florida | 51 | Final | W | 48 |
| 2 | 2015-09-12 | South Florida (104) | 14 | Florida State (2) | 34 | Final | L | -20 |
| 3 | 2015-09-19 | South Florida | 17 | Maryland | 35 | Final | L | -18 |
| 4 | 2015-10-02 | Memphis | 24 | South Florida | 17 | Final | L | -7 |
| 5 | 2015-10-10 | Syracuse | 24 | South Florida | 45 | Final | W | 21 |
| 6 | 2015-10-17 | South Florida | 28 | Connecticut | 20 | Final | W | 8 |
| 7 | 2015-10-24 | SMU | 14 | South Florida | 38 | Final | W | 24 |
| 8 | 2015-10-31 | South Florida | 17 | Navy | 29 | Final | L | -12 |
| 9 | 2015-11-07 | South Florida | 22 | East Carolina | 17 | Final | W | 5 |
| 10 | 2015-11-14 | Temple | 23 | South Florida | 44 | Final | W | 21 |
| 11 | 2015-11-20 | Cincinnati | 27 | South Florida | 65 | Final | W | 38 |
| 12 | 2015-11-26 | South Florida | 44 | Central Florida | 3 | Final | W | 41 |
| 13 | 2015-12-21 | Western Kentucky | 45 | South Florida | 35 | Final | L | -10 |