Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2015-09-05 | Towson | 20 | East Carolina | 28 | Final | W | 8 |
| 2 | 2015-09-12 | East Carolina (53) | 24 | Florida (35) | 31 | Final | L | -7 |
| 3 | 2015-09-19 | East Carolina (89) | 21 | Navy (56) | 45 | Final | L | -24 |
| 4 | 2015-09-26 | Virginia Tech (54) | 28 | East Carolina (99) | 35 | Final | W | 7 |
| 5 | 2015-10-03 | East Carolina (69) | 49 | SMU (120) | 23 | Final | W | 26 |
| 6 | 2015-10-10 | East Carolina (61) | 38 | BYU (39) | 45 | Final | L | -7 |
| 7 | 2015-10-17 | Tulsa (58) | 17 | East Carolina (68) | 30 | Final | W | 13 |
| 8 | 2015-10-22 | Temple (20) | 24 | East Carolina (61) | 14 | Final | L | -10 |
| 9 | 2015-10-30 | East Carolina | 13 | Connecticut | 31 | Final | L | -18 |
| 10 | 2015-11-07 | South Florida | 22 | East Carolina | 17 | Final | L | -5 |
| 11 | 2015-11-19 | East Carolina | 44 | Central Florida | 7 | Final | W | 37 |
| 12 | 2015-11-28 | Cincinnati (55) | 19 | East Carolina (75) | 16 | Final | L | -3 |