Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-08-30 | Northwestern (18) | 31 | Purdue (45) | 27 | Final | L | -4 |
| 2 | 2018-09-08 | Eastern Michigan | 20 | Purdue | 19 | Final | L | -1 |
| 3 | 2018-09-15 | Missouri (53) | 40 | Purdue (45) | 37 | Final | L | -3 |
| 4 | 2018-09-22 | Boston College (31) | 13 | Purdue (45) | 30 | Final | W | 17 |
| 5 | 2018-09-29 | Purdue (87) | 42 | Nebraska (113) | 28 | Final | W | 14 |
| 6 | 2018-10-13 | Purdue (81) | 46 | Illinois (74) | 7 | Final | W | 39 |
| 7 | 2018-10-20 | Ohio State (4) | 20 | Purdue (64) | 49 | Final | W | 29 |
| 8 | 2018-10-27 | Purdue (41) | 13 | Michigan State (42) | 23 | Final | L | -10 |
| 9 | 2018-11-03 | Iowa (15) | 36 | Purdue (47) | 38 | Final | W | 2 |
| 10 | 2018-11-10 | Purdue (34) | 10 | Minnesota (81) | 41 | Final | L | -31 |
| 11 | 2018-11-17 | Wisconsin (47) | 47 | Purdue (42) | 44 | Final/3OT | L | -3 |
| 12 | 2018-11-24 | Purdue (48) | 28 | Indiana (60) | 21 | Final | W | 7 |
| 13 | 2018-12-28 | Purdue (40) | 14 | Auburn (24) | 63 | Final | L | -49 |