Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-09-07 | Sam Houston State | 44 | Prairie View A&M | 31 | Final | L | -13 |
| 2 | 2017-09-16 | Prairie View A&M | 13 | Nicholls State | 44 | Final | L | -31 |
| 3 | 2017-09-23 | Prairie View A&M | 34 | Alabama State | 0 | Final | W | 34 |
| 4 | 2017-09-30 | Jackson State | 9 | Prairie View A&M | 38 | Final | W | 29 |
| 5 | 2017-10-07 | Grambling | 34 | Prairie View A&M | 21 | Final | L | -13 |
| 6 | 2017-10-14 | Prairie View A&M | 21 | Alcorn State | 34 | Final | L | -13 |
| 7 | 2017-10-28 | Bacone College | 17 | Prairie View A&M | 34 | Final | W | 17 |
| 8 | 2017-11-04 | Prairie View A&M | 31 | Southern | 37 | Final | L | -6 |
| 9 | 2017-11-11 | Arkansas-Pine Bluff | 12 | Prairie View A&M | 35 | Final | W | 23 |
| 10 | 2017-11-16 | Prairie View A&M | 42 | Incarnate Word | 28 | Final | W | 14 |
| 11 | 2017-11-25 | Prairie View A&M | 30 | Texas Southern | 16 | Final | W | 14 |