Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2019-08-31 | Florida Atlantic (95) | 21 | Ohio State (4) | 45 | Final | W | 24 |
| 2 | 2019-09-07 | Cincinnati (27) | 0 | Ohio State (4) | 42 | Final | W | 42 |
| 3 | 2019-09-14 | Ohio State (4) | 51 | Indiana (65) | 10 | Final | W | 41 |
| 4 | 2019-09-21 | Miami (OH) (80) | 5 | Ohio State (4) | 76 | Final | W | 71 |
| 5 | 2019-09-28 | Ohio State (1) | 48 | Nebraska (36) | 7 | Final | W | 41 |
| 6 | 2019-10-05 | Michigan State (14) | 10 | Ohio State (1) | 34 | Final | W | 24 |
| 7 | 2019-10-18 | Ohio State (1) | 52 | Northwestern (93) | 3 | Final | W | 49 |
| 8 | 2019-10-26 | Wisconsin (11) | 7 | Ohio State (1) | 38 | Final | W | 31 |
| 9 | 2019-11-09 | Maryland (87) | 14 | Ohio State (1) | 73 | Final | W | 59 |
| 10 | 2019-11-16 | Ohio State (1) | 56 | Rutgers (120) | 21 | Final | W | 35 |
| 11 | 2019-11-23 | Penn State (4) | 17 | Ohio State (1) | 28 | Final | W | 11 |
| 12 | 2019-11-30 | Ohio State (1) | 56 | Michigan (8) | 27 | Final | W | 29 |
| 13 | 2019-12-07 | Ohio State (1) | 34 | Wisconsin (5) | 21 | Final | W | 13 |
| 14 | 2019-12-28 | Clemson (3) | 29 | Ohio State (1) | 23 | Final | L | -6 |