Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-09-18 | Houston (87) | 0 | Memphis (13) | 0 | Cancelled | - | - |
| 2 | 2020-09-19 | Houston (87) | 0 | Baylor (19) | 0 | Cancelled | - | - |
| 3 | 2020-09-26 | North Texas (117) | 0 | Houston (87) | 0 | Cancelled | - | - |
| 4 | 2020-10-08 | Tulane (33) | 31 | Houston (56) | 49 | Final | W | 18 |
| 5 | 2020-10-16 | BYU (1) | 43 | Houston (17) | 26 | Final | L | -17 |
| 6 | 2020-10-24 | Houston (24) | 37 | Navy (34) | 21 | Final | W | 16 |
| 7 | 2020-10-31 | Central Florida (40) | 44 | Houston (19) | 21 | Final | L | -23 |
| 8 | 2020-11-07 | Houston (42) | 10 | Cincinnati (4) | 38 | Final | L | -28 |
| 9 | 2020-11-14 | South Florida (127) | 21 | Houston (53) | 56 | Final | W | 35 |
| 10 | 2020-11-21 | Houston (46) | 0 | SMU (29) | 0 | Cancelled | - | - |
| 11 | 2020-11-28 | Tulsa (20) | 0 | Houston (47) | 0 | Cancelled | - | - |
| 12 | 2020-12-05 | Houston (44) | 0 | Memphis (41) | 0 | Cancelled | - | - |
| 13 | 2020-12-05 | Houston (44) | 0 | SMU (40) | 0 | Cancelled | - | - |
| 14 | 2020-12-12 | Houston (44) | 27 | Memphis (58) | 30 | Final | L | -3 |
| 15 | 2020-12-24 | Hawaii (71) | 28 | Houston (58) | 14 | Final | L | -14 |