Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2019-09-01 | Houston (79) | 31 | Oklahoma (6) | 49 | Final | L | -18 |
| 2 | 2019-09-07 | Prairie View A&M (190) | 17 | Houston (79) | 37 | Final | W | 20 |
| 3 | 2019-09-13 | Washington State (17) | 31 | Houston (79) | 24 | Final | L | -7 |
| 4 | 2019-09-19 | Houston (79) | 31 | Tulane (84) | 38 | Final | L | -7 |
| 5 | 2019-09-28 | Houston (108) | 46 | North Texas (72) | 25 | Final | W | 21 |
| 6 | 2019-10-12 | Cincinnati (20) | 38 | Houston (81) | 23 | Final | L | -15 |
| 7 | 2019-10-19 | Houston (91) | 24 | Connecticut (132) | 17 | Final | W | 7 |
| 8 | 2019-10-24 | SMU (9) | 34 | Houston (83) | 31 | Final | L | -3 |
| 9 | 2019-11-02 | Houston (87) | 29 | Central Florida (25) | 44 | Final | L | -15 |
| 10 | 2019-11-16 | Memphis (15) | 45 | Houston (93) | 27 | Final | L | -18 |
| 11 | 2019-11-23 | Houston (94) | 24 | Tulsa (72) | 14 | Final | W | 10 |
| 12 | 2019-11-30 | Navy (21) | 56 | Houston (81) | 41 | Final | L | -15 |