Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-09-02 | Houston (34) | 0 | UTSA (92) | 0 | Postponed | - | - |
| 2 | 2017-09-09 | Houston (34) | 19 | Arizona (100) | 16 | Final | W | 3 |
| 3 | 2017-09-16 | Rice (136) | 3 | Houston (34) | 38 | Final | W | 35 |
| 4 | 2017-09-23 | Texas Tech (77) | 27 | Houston (34) | 24 | Final | L | -3 |
| 5 | 2017-09-30 | Houston (39) | 20 | Temple (83) | 13 | Final | W | 7 |
| 6 | 2017-10-07 | SMU (29) | 22 | Houston (45) | 35 | Final | W | 13 |
| 7 | 2017-10-14 | Houston (28) | 17 | Tulsa (102) | 45 | Final | L | -28 |
| 8 | 2017-10-19 | Memphis (22) | 42 | Houston (48) | 38 | Final | L | -4 |
| 9 | 2017-10-28 | Houston | 28 | South Florida | 24 | Final | W | 4 |
| 10 | 2017-11-04 | East Carolina (125) | 27 | Houston (38) | 52 | Final | W | 25 |
| 11 | 2017-11-18 | Houston (41) | 17 | Tulane (88) | 20 | Final | L | -3 |
| 12 | 2017-11-24 | Navy (38) | 14 | Houston (55) | 24 | Final | W | 10 |
| 13 | 2017-12-24 | Fresno State (37) | 33 | Houston (46) | 27 | Final | L | -6 |