Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2017-09-02 | James Madison | 34 | East Carolina | 14 | Final | L | -20 |
| 2 | 2017-09-09 | East Carolina (109) | 20 | West Virginia (24) | 56 | Final | L | -36 |
| 3 | 2017-09-16 | Virginia Tech (22) | 64 | East Carolina (109) | 17 | Final | L | -47 |
| 4 | 2017-09-24 | East Carolina | 41 | Connecticut | 38 | Final | W | 3 |
| 5 | 2017-09-30 | South Florida | 61 | East Carolina | 31 | Final | L | -30 |
| 6 | 2017-10-07 | Temple (94) | 34 | East Carolina (132) | 10 | Final | L | -24 |
| 7 | 2017-10-14 | East Carolina | 21 | Central Florida | 63 | Final | L | -42 |
| 8 | 2017-10-21 | BYU (123) | 17 | East Carolina (137) | 33 | Final | W | 16 |
| 9 | 2017-11-04 | East Carolina (125) | 27 | Houston (38) | 52 | Final | L | -25 |
| 10 | 2017-11-11 | Tulane (92) | 31 | East Carolina (129) | 24 | Final/OT | L | -7 |
| 11 | 2017-11-18 | Cincinnati (102) | 20 | East Carolina (131) | 48 | Final | W | 28 |
| 12 | 2017-11-25 | East Carolina (123) | 13 | Memphis (14) | 70 | Final | L | -57 |