Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Middle Tennessee | 7 | Vanderbilt | 35 | Final | W | 28 |
| 2 | 2018-09-08 | Nevada (116) | 10 | Vanderbilt (88) | 41 | Final | W | 31 |
| 3 | 2018-09-15 | Vanderbilt (88) | 17 | Notre Dame (10) | 22 | Final | L | -5 |
| 4 | 2018-09-22 | South Carolina (36) | 37 | Vanderbilt (88) | 14 | Final | L | -23 |
| 5 | 2018-09-29 | Tennessee State (154) | 27 | Vanderbilt (51) | 31 | Final | W | 4 |
| 6 | 2018-10-06 | Vanderbilt (57) | 13 | Georgia (5) | 41 | Final | L | -28 |
| 7 | 2018-10-13 | Florida (12) | 37 | Vanderbilt (56) | 27 | Final | L | -10 |
| 8 | 2018-10-20 | Vanderbilt (67) | 7 | Kentucky (10) | 14 | Final | L | -7 |
| 9 | 2018-10-27 | Vanderbilt (63) | 45 | Arkansas (107) | 31 | Final | W | 14 |
| 10 | 2018-11-10 | Vanderbilt (55) | 28 | Missouri (26) | 33 | Final | L | -5 |
| 11 | 2018-11-17 | Ole Miss (54) | 29 | Vanderbilt (60) | 36 | Final/OT | W | 7 |
| 12 | 2018-11-24 | Tennessee (52) | 13 | Vanderbilt (51) | 38 | Final | W | 25 |
| 13 | 2018-12-27 | Baylor (77) | 45 | Vanderbilt (38) | 38 | Final | L | -7 |