Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Ole Miss (65) | 47 | Texas Tech (63) | 27 | Final | L | -20 |
| 2 | 2018-09-08 | Lamar (242) | 0 | Texas Tech (63) | 77 | Final | W | 77 |
| 3 | 2018-09-15 | Houston (46) | 49 | Texas Tech (63) | 63 | Final | W | 14 |
| 4 | 2018-09-22 | Texas Tech (63) | 41 | Oklahoma State (21) | 17 | Final | W | 24 |
| 5 | 2018-09-29 | West Virginia (19) | 42 | Texas Tech (18) | 34 | Final | L | -8 |
| 6 | 2018-10-11 | Texas Tech (32) | 17 | TCU (37) | 14 | Final | W | 3 |
| 7 | 2018-10-20 | Kansas (112) | 16 | Texas Tech (28) | 48 | Final | W | 32 |
| 8 | 2018-10-27 | Texas Tech (28) | 31 | Iowa State (48) | 40 | Final | L | -9 |
| 9 | 2018-11-03 | Oklahoma (7) | 51 | Texas Tech (35) | 46 | Final | L | -5 |
| 10 | 2018-11-10 | Texas (33) | 41 | Texas Tech (39) | 34 | Final | L | -7 |
| 11 | 2018-11-17 | Texas Tech (45) | 6 | Kansas State (94) | 21 | Final | L | -15 |
| 12 | 2018-11-24 | Baylor (82) | 35 | Texas Tech (56) | 24 | Final | L | -11 |