Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | UT Permian Basin | 16 | Texas Southern | 26 | Final | W | 10 |
| 2 | 2018-09-08 | Texas Southern (243) | 20 | Texas State (157) | 36 | Final | L | -16 |
| 3 | 2018-09-15 | Texas Southern (243) | 15 | Alcorn State (183) | 27 | Final | L | -12 |
| 4 | 2018-09-22 | Texas Southern (243) | 14 | Houston (46) | 70 | Final | L | -56 |
| 5 | 2018-10-06 | Alabama A&M (216) | 42 | Texas Southern (217) | 21 | Final | L | -21 |
| 6 | 2018-10-13 | Grambling (201) | 34 | Texas Southern (240) | 21 | Final | L | -13 |
| 7 | 2018-10-20 | Texas Southern (244) | 7 | Southern (178) | 21 | Final | L | -14 |
| 8 | 2018-10-27 | Mississippi Valley State (247) | 14 | Texas Southern (244) | 42 | Final | W | 28 |
| 9 | 2018-11-03 | Texas Southern (235) | 21 | Alabama State (228) | 30 | Final | L | -9 |
| 10 | 2018-11-17 | Arkansas-Pine Bluff (255) | 15 | Texas Southern (240) | 10 | Final | L | -5 |
| 11 | 2018-11-24 | Texas Southern (244) | 14 | Prairie View A&M (196) | 60 | Final | L | -46 |