Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Bethune-Cookman | 3 | Tennessee State | 34 | Final | W | 31 |
| 2 | 2018-09-08 | Jackson State | 0 | Tennessee State | 0 | Canceled | – | – |
| 3 | 2018-09-15 | Tennessee State | 0 | Hampton | 0 | Canceled | – | – |
| 4 | 2018-09-22 | Tennessee State | 41 | Eastern Illinois | 40 | Final | W | 1 |
| 5 | 2018-09-29 | Tennessee State (154) | 27 | Vanderbilt (51) | 31 | Final | L | -4 |
| 6 | 2018-10-06 | Tennessee State (155) | 34 | Austin Peay (203) | 49 | Final | L | -15 |
| 7 | 2018-10-13 | Tennessee State (179) | 21 | Murray State (214) | 45 | Final | L | -24 |
| 8 | 2018-10-20 | Tennessee Tech (250) | 14 | Tennessee State (199) | 41 | Final | W | 27 |
| 9 | 2018-11-03 | Tennessee State (194) | 21 | Southeast Missouri State (151) | 38 | Final | L | -17 |
| 10 | 2018-11-10 | Jacksonville State (144) | 41 | Tennessee State (198) | 14 | Final | L | -27 |
| 11 | 2018-11-17 | Tennessee-Martin (224) | 28 | Tennessee State (209) | 31 | Final/OT | W | 3 |