Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Jackson State (240) | 7 | Southern Miss (72) | 55 | Final | W | 48 |
| 2 | 2018-09-08 | Louisiana-Monroe | 21 | Southern Miss | 20 | Final | L | -1 |
| 3 | 2018-09-15 | Southern Miss | 0 | Appalachian State | 0 | Postponed | – | – |
| 4 | 2018-09-22 | Rice (153) | 22 | Southern Miss (72) | 40 | Final | W | 18 |
| 5 | 2018-09-29 | Southern Miss (75) | 13 | Auburn (23) | 24 | Final | L | -11 |
| 6 | 2018-10-13 | Southern Miss (96) | 7 | North Texas (43) | 30 | Final | L | -23 |
| 7 | 2018-10-20 | UTSA (114) | 17 | Southern Miss (100) | 27 | Final | W | 10 |
| 8 | 2018-10-27 | Southern Miss (94) | 17 | Charlotte (105) | 20 | Final | L | -3 |
| 9 | 2018-11-03 | Marshall (68) | 24 | Southern Miss (104) | 26 | Final | W | 2 |
| 10 | 2018-11-10 | Southern Miss (95) | 23 | UAB (24) | 26 | Final/OT | L | -3 |
| 11 | 2018-11-17 | Louisiana Tech (59) | 20 | Southern Miss (99) | 21 | Final | W | 1 |
| 12 | 2018-11-24 | Southern Miss (95) | 39 | UTEP (179) | 7 | Final | W | 32 |