Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Coastal Carolina | 15 | South Carolina | 49 | Final | W | 34 |
| 2 | 2018-09-08 | Georgia (3) | 41 | South Carolina (36) | 17 | Final | L | -24 |
| 3 | 2018-09-15 | Marshall (64) | 0 | South Carolina (36) | 0 | Canceled | – | – |
| 4 | 2018-09-22 | South Carolina (36) | 37 | Vanderbilt (88) | 14 | Final | W | 23 |
| 5 | 2018-09-29 | South Carolina (16) | 10 | Kentucky (9) | 24 | Final | L | -14 |
| 6 | 2018-10-06 | Missouri (39) | 35 | South Carolina (31) | 37 | Final | W | 2 |
| 7 | 2018-10-13 | Texas A&M (21) | 26 | South Carolina (22) | 23 | Final | L | -3 |
| 8 | 2018-10-27 | Tennessee (69) | 24 | South Carolina (37) | 27 | Final | W | 3 |
| 9 | 2018-11-03 | South Carolina (30) | 48 | Ole Miss (51) | 44 | Final | W | 4 |
| 10 | 2018-11-10 | South Carolina (20) | 31 | Florida (14) | 35 | Final | L | -4 |
| 11 | 2018-11-17 | Chattanooga (183) | 9 | South Carolina (30) | 49 | Final | W | 40 |
| 12 | 2018-11-24 | South Carolina (26) | 35 | Clemson (2) | 56 | Final | L | -21 |
| 13 | 2018-12-01 | Akron (108) | 3 | South Carolina (28) | 28 | Final | W | 25 |
| 14 | 2018-12-29 | South Carolina (26) | 0 | Virginia (53) | 28 | Final | L | -28 |