Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Louisiana Tech | 30 | South Alabama | 26 | Final | L | -4 |
| 2 | 2018-09-08 | South Alabama (119) | 13 | Oklahoma State (21) | 55 | Final | L | -42 |
| 3 | 2018-09-15 | Texas State (157) | 31 | South Alabama (119) | 41 | Final | W | 10 |
| 4 | 2018-09-22 | South Alabama (119) | 35 | Memphis (14) | 52 | Final | L | -17 |
| 5 | 2018-09-29 | South Alabama (110) | 7 | Appalachian State (37) | 52 | Final | L | -45 |
| 6 | 2018-10-06 | South Alabama (113) | 13 | Georgia Southern (43) | 48 | Final | L | -35 |
| 7 | 2018-10-13 | Alabama State (225) | 7 | South Alabama (123) | 45 | Final | W | 38 |
| 8 | 2018-10-23 | Troy (62) | 38 | South Alabama (119) | 17 | Final | L | -21 |
| 9 | 2018-11-03 | South Alabama (118) | 14 | Arkansas State (93) | 38 | Final | L | -24 |
| 10 | 2018-11-10 | Louisiana-Monroe (92) | 38 | South Alabama (123) | 10 | Final | L | -28 |
| 11 | 2018-11-17 | South Alabama (128) | 38 | Louisiana (89) | 48 | Final | L | -10 |
| 12 | 2018-11-23 | Coastal Carolina (97) | 28 | South Alabama (131) | 31 | Final | W | 3 |