Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Albany | 7 | Pittsburgh | 33 | Final | W | 26 |
| 2 | 2018-09-08 | Penn State | 51 | Pittsburgh | 6 | Final | L | -45 |
| 3 | 2018-09-15 | Georgia Tech | 19 | Pittsburgh | 24 | Final | W | 5 |
| 4 | 2018-09-22 | Pittsburgh | 35 | North Carolina | 38 | Final | L | -3 |
| 5 | 2018-09-29 | Pittsburgh (88) | 14 | Central Florida (22) | 45 | Final | L | -31 |
| 6 | 2018-10-06 | Syracuse (19) | 37 | Pittsburgh (97) | 44 | Final/OT | W | 7 |
| 7 | 2018-10-13 | Pittsburgh (73) | 14 | Notre Dame (4) | 19 | Final | L | -5 |
| 8 | 2018-10-27 | Duke (33) | 45 | Pittsburgh (77) | 54 | Final | W | 9 |
| 9 | 2018-11-02 | Pittsburgh (58) | 23 | Virginia (39) | 13 | Final | W | 10 |
| 10 | 2018-11-10 | Virginia Tech (77) | 22 | Pittsburgh (46) | 52 | Final | W | 30 |
| 11 | 2018-11-17 | Pittsburgh (39) | 34 | Wake Forest (74) | 13 | Final | W | 21 |
| 12 | 2018-11-24 | Pittsburgh (32) | 3 | Miami (46) | 24 | Final | L | -21 |
| 13 | 2018-12-01 | Clemson (2) | 42 | Pittsburgh (37) | 10 | Final | L | -32 |
| 14 | 2018-12-31 | Stanford (32) | 14 | Pittsburgh (37) | 13 | Final | L | -1 |