Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Appalachian State | 38 | Penn State | 45 | Final/OT | W | 7 |
| 2 | 2018-09-08 | Penn State | 51 | Pittsburgh | 6 | Final | W | 45 |
| 3 | 2018-09-15 | Kent State (136) | 10 | Penn State (8) | 63 | Final | W | 53 |
| 4 | 2018-09-21 | Penn State (8) | 63 | Illinois (121) | 24 | Final | W | 39 |
| 5 | 2018-09-29 | Ohio State (10) | 27 | Penn State (3) | 26 | Final | L | -1 |
| 6 | 2018-10-13 | Michigan State (53) | 21 | Penn State (7) | 17 | Final | L | -4 |
| 7 | 2018-10-20 | Penn State (17) | 33 | Indiana (53) | 28 | Final | W | 5 |
| 8 | 2018-10-27 | Iowa (14) | 24 | Penn State (16) | 30 | Final | W | 6 |
| 9 | 2018-11-03 | Penn State (12) | 7 | Michigan (4) | 42 | Final | L | -35 |
| 10 | 2018-11-10 | Wisconsin (44) | 10 | Penn State (12) | 22 | Final | W | 12 |
| 11 | 2018-11-17 | Penn State (11) | 20 | Rutgers (131) | 7 | Final | W | 13 |
| 12 | 2018-11-24 | Maryland (58) | 3 | Penn State (12) | 38 | Final | W | 35 |
| 13 | 2019-01-01 | Kentucky (12) | 27 | Penn State (11) | 24 | Final | L | -3 |