Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Old Dominion (112) | 10 | Liberty (180) | 52 | Final | L | -42 |
| 2 | 2018-09-08 | Florida International | 28 | Old Dominion | 20 | Final | L | -8 |
| 3 | 2018-09-13 | Old Dominion (112) | 25 | Charlotte (164) | 28 | Final | L | -3 |
| 4 | 2018-09-22 | Virginia Tech (20) | 35 | Old Dominion (112) | 49 | Final | W | 14 |
| 5 | 2018-09-29 | Old Dominion (107) | 35 | East Carolina (105) | 37 | Final | L | -2 |
| 6 | 2018-10-06 | Old Dominion (111) | 33 | Florida Atlantic (95) | 52 | Final | L | -19 |
| 7 | 2018-10-13 | Marshall (79) | 42 | Old Dominion (122) | 20 | Final | L | -22 |
| 8 | 2018-10-20 | Old Dominion (125) | 37 | Western Kentucky (140) | 34 | Final | W | 3 |
| 9 | 2018-10-27 | Middle Tennessee (74) | 51 | Old Dominion (120) | 17 | Final | L | -34 |
| 10 | 2018-11-10 | North Texas (42) | 31 | Old Dominion (129) | 34 | Final | W | 3 |
| 11 | 2018-11-17 | Virginia Military (251) | 14 | Old Dominion (116) | 77 | Final | W | 63 |
| 12 | 2018-11-24 | Old Dominion (112) | 13 | Rice (169) | 27 | Final | L | -14 |