Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Oregon State (149) | 31 | Ohio State (5) | 77 | Final | W | 46 |
| 2 | 2018-09-08 | Rutgers (99) | 3 | Ohio State (5) | 52 | Final | W | 49 |
| 3 | 2018-09-15 | Ohio State (5) | 40 | TCU (15) | 28 | Final | W | 12 |
| 4 | 2018-09-22 | Tulane (82) | 6 | Ohio State (5) | 49 | Final | W | 43 |
| 5 | 2018-09-29 | Ohio State (10) | 27 | Penn State (3) | 26 | Final | W | 1 |
| 6 | 2018-10-06 | Indiana (28) | 26 | Ohio State (4) | 49 | Final | W | 23 |
| 7 | 2018-10-13 | Minnesota (49) | 14 | Ohio State (2) | 30 | Final | W | 16 |
| 8 | 2018-10-20 | Ohio State (4) | 20 | Purdue (64) | 49 | Final | L | -29 |
| 9 | 2018-11-03 | Nebraska (97) | 31 | Ohio State (11) | 36 | Final | W | 5 |
| 10 | 2018-11-10 | Ohio State (10) | 26 | Michigan State (18) | 6 | Final | W | 20 |
| 11 | 2018-11-17 | Ohio State (9) | 52 | Maryland (55) | 51 | Final/OT | W | 1 |
| 12 | 2018-11-24 | Michigan (5) | 39 | Ohio State (9) | 62 | Final | W | 23 |
| 13 | 2018-12-01 | Northwestern (32) | 24 | Ohio State (7) | 45 | Final | W | 21 |
| 14 | 2019-01-01 | Washington (19) | 23 | Ohio State (6) | 28 | Final | W | 5 |