Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Howard (168) | 32 | Ohio (42) | 38 | Final | W | 6 |
| 2 | 2018-09-15 | Ohio (42) | 31 | Virginia (66) | 45 | Final | L | -14 |
| 3 | 2018-09-22 | Ohio (42) | 30 | Cincinnati (107) | 34 | Final | L | -4 |
| 4 | 2018-09-29 | Massachusetts (100) | 42 | Ohio (98) | 58 | Final | W | 16 |
| 5 | 2018-10-06 | Ohio (79) | 27 | Kent State (126) | 26 | Final | W | 1 |
| 6 | 2018-10-13 | Ohio (82) | 21 | Northern Illinois (87) | 24 | Final | L | -3 |
| 7 | 2018-10-20 | Bowling Green (135) | 14 | Ohio (88) | 49 | Final | W | 35 |
| 8 | 2018-10-25 | Ball State (114) | 14 | Ohio (83) | 52 | Final | W | 38 |
| 9 | 2018-11-01 | Ohio (80) | 59 | Western Michigan (64) | 14 | Final | W | 45 |
| 10 | 2018-11-07 | Ohio (62) | 28 | Miami (OH) (100) | 30 | Final | L | -2 |
| 11 | 2018-11-14 | Buffalo (19) | 17 | Ohio (72) | 52 | Final | W | 35 |
| 12 | 2018-11-23 | Akron (104) | 28 | Ohio (55) | 49 | Final | W | 21 |
| 13 | 2018-12-19 | San Diego State (80) | 0 | Ohio (51) | 27 | Final | W | 27 |