Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-08-30 | Northwestern (18) | 31 | Purdue (45) | 27 | Final | W | 4 |
| 2 | 2018-09-08 | Duke (61) | 21 | Northwestern (18) | 7 | Final | L | -14 |
| 3 | 2018-09-15 | Akron (71) | 39 | Northwestern (18) | 34 | Final | L | -5 |
| 4 | 2018-09-29 | Michigan (17) | 20 | Northwestern (79) | 17 | Final | L | -3 |
| 5 | 2018-10-06 | Northwestern (78) | 29 | Michigan State (29) | 19 | Final | W | 10 |
| 6 | 2018-10-13 | Nebraska (118) | 31 | Northwestern (68) | 34 | Final/OT | W | 3 |
| 7 | 2018-10-20 | Northwestern (59) | 18 | Rutgers (130) | 15 | Final | W | 3 |
| 8 | 2018-10-27 | Wisconsin (29) | 17 | Northwestern (56) | 31 | Final | W | 14 |
| 9 | 2018-11-03 | Notre Dame (3) | 31 | Northwestern (42) | 21 | Final | L | -10 |
| 10 | 2018-11-10 | Northwestern (40) | 14 | Iowa (29) | 10 | Final | W | 4 |
| 11 | 2018-11-17 | Northwestern (35) | 24 | Minnesota (65) | 14 | Final | W | 10 |
| 12 | 2018-11-24 | Illinois (106) | 16 | Northwestern (31) | 24 | Final | W | 8 |
| 13 | 2018-12-01 | Northwestern (32) | 24 | Ohio State (7) | 45 | Final | L | -21 |
| 14 | 2018-12-31 | Northwestern (33) | 31 | Utah (27) | 20 | Final | W | 11 |