Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-09-01 | Nicholls State | 26 | Kansas | 23 | Final/OT | W | 3 |
| 2 | 2018-09-08 | Nicholls State | 17 | Tulane | 42 | Final | L | -25 |
| 3 | 2018-09-15 | Nicholls State | 10 | McNeese State | 20 | Final | L | -10 |
| 4 | 2018-09-22 | Sam Houston State | 7 | Nicholls State | 27 | Final | W | 20 |
| 5 | 2018-09-29 | Lamar (230) | 27 | Nicholls State (142) | 50 | Final | W | 23 |
| 6 | 2018-10-06 | Nicholls State (139) | 28 | Northwestern State (190) | 10 | Final | W | 18 |
| 7 | 2018-10-13 | Nicholls State (131) | 12 | Abilene Christian (221) | 28 | Final | L | -16 |
| 8 | 2018-10-27 | Incarnate Word (155) | 21 | Nicholls State (148) | 48 | Final | W | 27 |
| 9 | 2018-11-03 | Nicholls State (134) | 41 | Houston Baptist (246) | 20 | Final | W | 21 |
| 10 | 2018-11-10 | Stephen F. Austin (223) | 14 | Nicholls State (136) | 47 | Final | W | 33 |
| 11 | 2018-11-15 | Southeastern Louisiana (187) | 0 | Nicholls State (135) | 44 | Final | W | 44 |
| 12 | 2018-11-24 | San Diego (153) | 30 | Nicholls State (128) | 49 | Final | W | 19 |
| 13 | 2018-12-01 | Nicholls State (126) | 21 | Eastern Washington (111) | 42 | Final | L | -21 |